abstract |
Compounds of formula (I) wherein R and R are the same or different and are each optionally substituted alkyl, optionally substitued cycloalkyl, optionally subsituted aryl or optianally substituted heteroaryl groups; R is hydrogen or an aryl group substituent or R is a solid support optionally attached via a spacer; Z represents an oxygen atom, a sulphur atom or NR; Y represents an oxygen atom, a sulphur atom or NR; in which R and R, which may be the same or different, represent hydrogen, optionally substituted alkyl containing 1 to 6 carbon atoms, optionally substituted phenyl, optionally substituted benzyl or optionally substituted β-phenylethyl; and one of X and X represents a nitrogen atom and the other of X and X represents a nitrogen atom or CR, in which R represents hydrogen or an aryl group substituent; are useful for the affinity binding of a prion protein. |