| abstract |
1-heterocyclyl-1,5-dihydro-pyrido[3,2-b]indo l-2-ones of formula (I): the -oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereo f, wherein n is 1, 2 or 3; R is hydrogen, cyano, halo, substituted carbonyl, methanimidamidyl, -hydroxy- methanimidamidyl, mono- or di(Calkyl)methanimidamidyl, Het or Het; X is NR, O, S, SO, SO; R is hydrogen, Calkyl, Calkenyl, Ccycloalkyl, which are optionally substituted; R is aryl subst ituted with -COOR ; or R is: (b-1); (b-2); -CH-CH(OR)-CH-R (b-3); -CH-CH-(O-CH -CH)-OR (b-4); -CH-CH-(O-CH-CH)-NRR (b-5); -a=a-a=a- is -CH=CH-CH=CH-; -N=CH-CH=CH-; -CH=N-CH=CH-; -CH=CH-N=CH-; -CH=CH-CH=N-; wherein hydrogen atoms in (c-1) - (c-5) may be replaced by certain radicals; R is a monocyclic or bicyclic aromatic heterocyclic ring system that can be substituted. |