| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a799d17d5f808bee28dc9a15345a54f |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-227
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-088
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-495
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-0239 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-088
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-67
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-22 |
| filingDate |
2004-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2011-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_82b3101f638db281e6c39192df025b20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca203b0ecaf7b6dc69d85b4fc6285928
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e7256fccc17543b9d1908745c5f21a84
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e53b462a7cac8358d322c07a239dc3c |
| publicationDate |
2011-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
AU-2004323810-B2 |
| titleOfInvention |
Novel intermediates useful for the preparation of aripiprazole and methods for the preparation of the novel intermediates and aripiprazole |
| abstract |
The invention disclosed in this application relates to an improved process for the preparation of aripiprazole (1) which comprises (i) Reacting 6-hydroxy-l-indanone (11) with 1,4-dihalobutane (12) in the presence of a base and a solvent at a temperature in the range of 90 to 110 deg C to form the novel intermediate 6-(4-halo butoxy)-indan-l-one (3), (ii) reacting the novel intermediate with 1-(2,3-clichlorophenyl)-piperazine (9) to get another novel intermediate 6-[4-[4-(2,3-dichlorophenyl)-l-piperazinyl] butoxy]-indan-l-one (2) and (iii) Reacting the resulting novel compound with sodium azide. The invention also relates to the novel intermediates of the formulae (2) & (3) and processes for their preparation. |
| priorityDate |
2004-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |