| abstract |
Compounds for use in pharmaceutical compositions and methods for modulating the activity of nuclear receptors are provided. In particular, compounds for use in compositions and methods for modulating the farnesoid X receptor, and/or orphan nuclear receptors, are provided.: formula (I) or a pharmaceutically acceptable derivative thereof; wherein: Ris -C(J)OR, -C(J)SRand -C(J)N(R)R, J is O, S or NR, R is hydrogen, halo or optionally substituted alkyl; R is -C(O)R, R, R, R and R and R are as described in the claims. |