abstract |
PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF (METHYL-, ETHYL- OR ETHENYL) DIPHENYL PIPERIDINES OF FORMULA I, R1 IS CH, C = CH O CH-CH2, R2 IS ALKYLENE OR CARBONYLALKYLENE, R3 AND R4 ARE H, HALOGEUM OR ALCOXYL. , HET IS PIRIDILO, PIRIMIDINILO OR IMIDAZOLILO AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS, REACTS A FORMULA II COMPOUND WITH A HALOGENIDE HAL-R2-HET, WHERE R1 TO R4 AND HET ARE YES DEFINED, YES DESO, UNIDO OBTAINED FROM FORMULA I, WHERE R2 CONTAINS A GROUP OF CARBONYL, TO THE CORRESPONDING COMPOUND OF FORMULA I, WHERE R2 IS ALKYLENE. THESE COMPOUNDS EXHIBIT LOWERING INSULIN ACTIVITY AS AGENTS FOR OBESITY TREATMENT. |