http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-119305-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dab7fd26f3cb605aab550ed208a2fe8c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J63-008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J43-003 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J63-002 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J63-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J61-00 |
| filingDate | 2020-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a27f885e03138a51bdea26e21efdda72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1aac8053822d4ada2e40813b8ab5ab80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a0da458ce59b5713c0eefe228568c00f |
| publicationDate | 2021-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-119305-A1 |
| titleOfInvention | COMPOSITIONS AND METHODS FOR THE TREATMENT OF CNS DISORDERS |
| abstract | Claim 1: A compound of the formula (1) or a pharmaceutically acceptable salt thereof; characterized in that: ⁻ ⁻ ⁻ ⁻ ⁻ represents a single or double bond, provided that a double bond is present, then one of R⁶ᵃ or R⁶ᵇ is absent and R⁵ is absent; RX is selected from the group consisting of halo, -OH, -ORQ¹, and substituted or unsubstituted alkyl, where RQ¹ is substituted or unsubstituted alkyl; RY is halo or substituted or unsubstituted alkyl or RY and RX may join with the intervening atoms to form a substituted or unsubstituted carbocyclyl or a substituted or unsubstituted heterocyclyl; R³ is selected from the group consisting of substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl. substituted; R⁵ is hydrogen or methyl; each instance of R²² is independently selected from the group consisting of halogen, -NO₂, -CN, -ORGA, -N(RGA)₂, -C(=O)RGA, -C(=O)ORGA, -OC(= O)RGA, -OC(=O)ORGA, -C(=O)N(RGA)₂, -N(RGA)C(=O)RGA, -OC(=O)N(RGA)₂, -N (RGA)C(=O)ORGA, -N(RGA)C(=O)N(RGA)₂, -SRGA, -S(=O)RGA, S(=O)₂RGA, -S(=O) ₂ORGA, -OS(=O)₂RGA, -S(=O)₂N(RGA)₂, -N(RGA)S(=O)₂RGA, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl substituted, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl, wherein each instance of RGA is independently selected from the group consisting of hydrogen, substituted or unsubstituted C₁₋₆ alkyl, Substituted or unsubstituted C₂₋₆ alkenyl, Substituted or unsubstituted C₂₋₆ alkynyl, Substituted or unsubstituted C₃₋₆ carbocyclyl, Substituted or unsubstituted 3- to 6-membered heterocyclyl, Substituted or unsubstituted aryl, Substituted heteroaryl or unsubstituted, an oxygen protecting group when attached to oxygen and a nitrogen protecting group when attached to nitrogen, or two RGA groups are taken with the intervening atoms to form a substituted or unsubstituted heterocyclic or heteroaryl ring; R¹ᵃ, R¹ᵇ, R²ᵃ, R²ᵇ, R⁴ᵃ, R⁴ᵇ, R⁷ᵃ, R⁷ᵇ, R¹¹ᵃ, R¹¹ᵇ, R¹²ᵃ and R¹²ᵇ are each independently selected from the group consisting of hydrogen, halogen, cyano, -NO₂, substituted or unsubstituted alkyl, alkenyl or unsubstituted, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, -ORA¹, -N(RA¹)₂, -SRA¹, -C( =O)RA¹, -C(=O)ORA¹, -C(=O)SRA¹, -C(=O)N(RA¹)₂, -OC(=O)RA¹, -OC(=O)ORA¹, - OC(=O)N(RA¹)₂, -OC(=O)SRA¹, -OS(=O)₂RA¹, -OS(=O)₂ORA¹, -OS(=O)₂N(RA¹)₂, -N( RA¹)C(=O)RA¹, -N(RA¹)C(=NRA¹)RA¹, -N(RA¹)C(=O)ORA¹, -N(RA¹)C(=O)N(RA¹)₂, - N(RA¹)C(=NRA¹)N(RA¹)₂, -N(RA¹)S(=O)₂RA¹, -N(RA¹)S(=O)₂ORA¹, -N(RA¹)S(=O)₂N (RA¹)₂, -SC(=O)RA¹, -SC(=O)ORA¹, -SC(=O)SRA¹, -SC(=O)N(RA¹)₂, -S(=O)₂RA¹, - S(=O)₂ORA¹ or -S(=O)₂N(RA¹)₂, where each instance of RA¹ is independently selected from the group consisting of hydrogen, substituted or unsubstituted C₁₋₆ alkyl substituted or unsubstituted C₂₋₆ alkenyl, substituted or unsubstituted C₂₋₆ alkynyl, substituted or unsubstituted C₃₋₆ carbocyclyl, or substituted or unsubstituted 3- to 6-membered heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl substituted, an oxygen protecting group when attached to oxygen, a nitrogen protecting group when attached to nitrogen, and a sulfur protecting group when attached to sulfur, or two RA¹ groups are taken with the intervening atoms to form a ring substituted or unsubstituted heterocyclic; R⁶ᵃ and R⁶ᵇ are each independently selected from the group consisting of hydrogen, halogen, cyano, -NO₂, -OH, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, and substituted or unsubstituted alkynyl; or R⁶ᵃ and R⁶ᵇ come together to form an oxo (=O) group; R¹⁵ᵃ, R¹⁵ᵇ, R¹⁶ᵃ, and R¹⁶ᵇ are each independently selected from the group consisting of hydrogen, halogen, -CN, -NO₂, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted carbocyclyl or unsubstituted, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, -ORC³, -N(RC³)₂, -SRC³, -C(=O)RC³, -C(=O)ORC³ , -C(=O)SRC³, -C(=O)N(RC³)₂, -OC(=O)RC³, -OC(=O)ORC³, -OC(=O)N(RC³)₂, - OC(=O)SRC³, -OS(=O)₂RC³, -OS(=O)₂ORC³, -OS(=O)₂N(RC³)₂, -N(RC³)C(=O)RC³, -N( RC³)C(=NRC³)RC³, -N(RC³)C(=O)ORC³, -N(RC³)C(=O)N(RC³)₂, -N(RC³)C(=NRC³)N(RC³ )₂, -N(RC³)S(=O)₂RC³, -N(RC³)S(=O)₂ORC³, -N(RC³)S(=O)₂N(RC³)₂, -SC(=O)RC³ , -SC(=O)ORC³, -SC(=O)SRC³, -SC(=O)N(RC³)₂, -S(=O)₂RC³, -S(=O)₂ORC³, or -S(= O)₂N(RC³), where each instance of RC³ is independently selected from the group consisting of hydrogen, substituted or unsubstituted C₁₋₆ alkyl, substituted C₂₋₆ alkenyl tuido or unsubstituted, substituted or unsubstituted C₂₋₆ alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted carbocyclyl or substituted or unsubstituted heterocyclyl, an oxygen protecting group when bonded with oxygen, a nitrogen protecting group when bonded with nitrogen and a sulfur protecting group when bonded with sulfur, or two RC³ groups are taken with the intervening atoms to form a substituted or unsubstituted heterocyclic ring; R¹⁹ is hydrogen or substituted or unsubstituted alkyl; n is 0, 1, 2 or 3; and t is 2 or 3. |
| priorityDate | 2019-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 42.