| abstract |
Claim 1: A compound of formula (1), or a pharmaceutically acceptable salt thereof, and/or deuterates, solvates, racemic mixtures, enantiomers, diastereomers, and tautomers thereof, wherein X is N or CR³; Y is N or CR⁴; R¹, R², R³, and R⁴ are independently selected from H, halogen, -OH, -CN, -NH₂, C₁₋₆ alkyl, C₁₋₆ haloalkyl, -O(C₁₋₆ alkyl), -NH(C₁₋₆ alkyl ), or -N(C₁₋₆ alkyl)₂; Z is O, NR⁵, or CR⁶R⁷; R⁵ is selected from H, C₁₋₆ alkyl, or C₃₋₆ cycloalkyl; R⁶ and R⁷ are independently selected from H, halogen, -CN, C₁₋₆ haloalkyl, -O(C₁₋₆ haloalkyl), -OH, C₁₋₆ alkyl, C₃₋₆ cycloalkyl, or -O(C₁₋₆ alkyl) ; Ring A is phenyl, 5-6 membered heteroaryl, or indazolyl, each of which is optionally substituted with one or more groups selected from halogen, -CN, C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₁₋₆ haloalkyl, -NH₂, -NH(C₁₋₆ alkyl), -N(C₁₋₆ alkyl)₂, -O(C₁₋₆ alkyl), or -O(C₁₋₆ haloalkyl); Ring B is pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, or triazinyl, each of which is optionally substituted with one or more groups selected from halogen, -(C₁₋₆ alkyl)ₙ-CN, -NO₂, C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₁₋₆ haloalkyl, -(C₁₋₆ alkyl)ₙ-C₃₋₆ cycloalkyl, -(C₁₋₆ alkyl)ₙ-phenyl, -(C₁₋₆ alkyl)ₙ-heterocyclyl 4-6 membered, -(C₁₋₆ alkyl)ₙ-5-6 membered heteroaryl, -(C₁₋₆ alkyl)ₙ-NR¹’R²’, -(C₁₋₆ alkyl)ₙ-CONR¹’R²’, -(C₁₋₆ alkyl)ₙ-NR¹’R²’C(O)R³’, -(C₁₋₆ alkyl)ₙ-C(O)R³’, -(C₁₋₆ alkyl)ₙ-C(O)OR⁴ ’, -(C₁₋₆ alkyl)ₙ-OR⁵’, -(C₁₋₆ alkyl)ₙ-S(O)ₘNR¹’R²’, -(C₁₋₆ alkyl)ₙ-NR¹’R²’S(O)ₘR⁶ ', -(C₁₋₆ alkyl)ₙ-S(O)ₘR⁶', and -(C₁₋₆ alkyl)ₙ-SR⁷'; wherein each of said phenyl, C₃₋₆ cycloalkyl, 4-6 membered heterocyclyl, and 5-6 membered heteroaryl is optionally substituted with one or more groups selected from halogen, -CN, -OH, -NH₂, C₁ ₋₆ haloalkyl, -O(C₁₋₆ haloalkyl), C₁₋₆ alkyl, -O(C₁₋₆ alkyl), -NH(C₁₋₆ alkyl), -N(C₁₋₆ alkyl)₂, C₂₋₆ alkenyl , C₂₋₆ alkynyl, and C₃₋₆ cycloalkyl; n is 0 or 1; m is 1 or 2; p is 0 or 1; R¹', R²', R³', R⁴', R⁵', R⁶', and R⁷' are independently selected from H, C₁₋₆ alkyl, C₁₋₆ haloalkyl, -(C₁₋₆ alkyl)-O-(C₁₋ ₆ alkyl), -(C₁₋₆ alkyl)-OH, -(C₁₋₆ alkyl)-CN, -(C₁₋₆ alkyl)-NH₂, or C₃₋₆ cycloalkyl; or R¹' and R²' together with the N atom to which they are attached form a 4-6 membered heterocyclic ring. |