| abstract |
Claim 8: The pharmaceutical composition of any of claims 1 to 7, characterized in that the antibody-drug conjugate has the structure of formula (3). Claim 12: The pharmaceutical composition of claim 10, characterized in that the linker has a formula of: -Aₐ-Wʷ-Yʸ-; where -A- is a unit of extension, a is 0 or 1; -W- is an amino acid unit, w is an integer ranging from 0 to 12; and -Y- is a spacer unit, and is 0, 1, or 2. Claim 13: The pharmaceutical composition of claim 12, characterized in that the extension unit has the structure of formula (1); the amino acid unit is valine citrulline; and the spacer unit is a PAB group comprising the structure of formula (2). |