abstract |
A sterile hydrogel composition comprising a cross-linked polymer, wherein the cross-linked polymer is an oxidation product of a thiol-modified hyaluronan and wherein the thiol-modified hyaluronan has a degree of hyaluronan modification with thiol moieties of greater than about 80 mmol per gram of polymer, wherein the thiol-modified hyaluronan has a degree of hyaluronan modification with thiol moieties of less than about 280 mmol per gram of polymer, wherein the composition has a residual thiol content of less than 20% with regarding the degree of modification of the thiol-modified hyaluronan. |