http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-117387-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dab7fd26f3cb605aab550ed208a2fe8c |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J73-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-58 |
| filingDate | 2019-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_75c0fcfc4ebbe8611b4be27d11337eac http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1aac8053822d4ada2e40813b8ab5ab80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e7809cccf16f8e16a589e38aeaee26c7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a0da458ce59b5713c0eefe228568c00f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_60971a303a5cfcae8e19d96d55b51b24 |
| publicationDate | 2021-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-117387-A1 |
| titleOfInvention | COMPOSITIONS AND METHODS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS |
| abstract | A compound of formula (1) or its pharmaceutically acceptable salt, the variables of which are defined in the specification. Also provided are pharmaceutical compositions comprising a compound of formula (1), and methods of using the compounds, for example in the treatment of disorders related to the central nervous system. Claim 1: A compound of formula (1) or a pharmaceutically acceptable salt thereof, where m is 0, 1, or 2; X is -O-, -N (RX) -, or -S (O) ʸ-, where RX is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl , substituted or unsubstituted heterocycle, substituted or unsubstituted aryl, -S (O) ₂ (RA⁰), -C (O) (RA⁰), or substituted or unsubstituted heteroaryl, where each instance of RA⁰ is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocycle, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, and y is 0, 1, or 2; R³ᵃ is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocycle, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R¹⁹ is hydrogen, substituted or unsubstituted alkyl, C₂₋₆ substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl; R⁵ is hydrogen or methyl; R¹ is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocycle, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, -ORA¹, -SRA¹, -N (RA¹) ₂, -OC (= O) RA¹, -OC (= O) ORA¹, -OC (= O) SRA¹, -OC (= O) N (RA¹) ₂, -SC (= O) RA² , -SC (= O) ORA¹, -SC (= O) SRA¹, -SC (= O) N (RA¹) ₂, -NHC (= O) RA¹, -NHC (= O) ORA¹, -NHC (= O ) SRA¹, -NHC (= O) N (RA¹) ₂, -OS (= O) ₂RA², -OS (= O) ₂ORA¹, -SS (= O) ₂RA², -SS (= O) ₂ORA¹, -S ( = O) RA², -SO₂RA², or -S (= O) ₂ORA¹, where each RA¹ instance is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl substituted, substituted or unsubstituted heterocycle, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, an oxygen protecting group when attached to an oxygen atom, a sulfur protecting group when it is a attached to a sulfur atom, a nitrogen protecting group when attached to a nitrogen atom, or two RA¹ groups are attached to form a substituted or unsubstituted heterocyclic or heteroaryl ring; and RA² is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocycle, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; each of R¹⁵ᵃ, R¹⁵ᵇ, R¹⁶ᵃ, and R¹⁶ᵇ is independently hydrogen, halogen, cyano, hydroxyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted heterocycle, or unsubstituted, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, -ORA¹, -SRA¹, -N (RA¹) ₂, -CN (RA¹) ₂, -C (O) RA¹, -OC (= O) RA¹, -OC (= O) ORA¹, -OC (= O) SRA¹, -OC (= O) N (RA¹) ₂, -SC (= O) RA², -SC (= O) ORA¹, -SC (= O) SRA¹, -SC (= O) N (RA¹) ₂, -NHC (= O) RA¹, -NHC (= O) ORA¹, -NHC (= O) SRA¹, -NHC (= O) N (RA¹) ₂, -OS (= O) ₂RA², -OS (= O) ₂ORA¹, -SS (= O) ₂RA², -SS (= O) ₂ORA¹, -S (= O) RA², -SO₂RA², or -S (= O) ₂ORA¹, where each RA¹ instance is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocycle, substituted or unsubstituted aryl, heteroaryl substituted or not substituted or, an oxygen protecting group when attached to an oxygen atom, a sulfur protecting group when attached to a sulfur atom, a nitrogen protecting group when attached to a nitrogen atom, -SO₂RA², -C ( O) RA², or two RA¹ groups join to form a substituted or unsubstituted heterocyclic or heteroaryl ring; and RA² is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocycle, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; or R¹⁵ᵃ and R¹⁵ᵇ or R¹⁶ᵃ and R¹⁶ᵇ join to form an oxo group (= O); and each of R¹ᵃ, R¹ᵇ, R²ᵃ, R²ᵇ, R⁴ᵃ, R⁴ᵇ, R⁷ᵃ, R⁷ᵇ, R¹¹ᵃ, R¹¹ᵇ, R¹²ᵃ, and R¹²ᵇ is independently hydrogen, halogen, cyano, hydroxyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl substituted, substituted or unsubstituted heterocycle, or substituted or unsubstituted alkynyl, -ORD¹, -OC (= O) RD¹, -NH₂, -N (RD¹) ₂, or -NRD¹C (= O) RD¹, where each instance of RD¹ is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocycle, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, a oxygen protecting group when attached to an oxygen atom, a nitrogen protecting group when attached to a nitrogen atom, or two RD¹ groups are attached to form a substituted or unsubstituted heterocyclic ring; or any of R²ᵃ and R²ᵇ, R⁴ᵃ and R⁴ᵇ, R⁷ᵃ and R⁷ᵇ, R¹¹ᵃ and R¹¹ᵇ, and R¹²ᵃ and R¹²ᵇ join to form an oxo group (= O), where if m is 0, then R¹ is substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocycle, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, -ORA¹, -SRA¹, -N (RA¹) ₂, -OC (= O) RA¹ , -OC (= O) ORA¹, -OC (= O) SRA¹, -OC (= O) N (RA¹) ₂, -SC (= O) RA², -SC (= O) ORA¹, -SC (= O ) SRA¹, -SC (= O) N (RA¹) ₂, -NHC (= O) RA¹, -NHC (= O) ORA¹, -NHC (= O) SRA¹, -NHC (= O) N (RA¹) ₂ , -OS (= O) ₂RA², -OS (= O) ₂ORA¹, -SS (= O) ₂RA², -SS (= O) ₂ORA¹, -S (= O) RA², -SO₂RA², or -S (= O ) ₂ORA¹, where each RA¹ instance is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocycle, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, a pro group oxygen tector when attached to an oxygen atom, a sulfur protecting group when attached to a sulfur atom, a nitrogen protecting group when attached to a nitrogen atom, or two RA¹ groups bond to form a ring heterocyclic or substituted or unsubstituted heteroaryl; and RA² is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocycle, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl. |
| priorityDate | 2018-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 29.