| abstract |
Claim 1: A compound of formula (1) or a tautomer, isotopologue, stereoisomer or pharmaceutically acceptable salt thereof, wherein RN is H; each R¹ is independently selected from halogen, CN, and C₁₋₃ alkyl; each of R² and R³ is independently selected from H and C₁₋₃ alkyl, or R² and R³ and the carbon to which they are attached form a substituted or unsubstituted C₃₋₆ cycloalkyl; each R⁴ is independently substituted or unsubstituted C₁₋₃ alkyl, or two R⁴ groups, together with the same carbon atom or adjacent carbon atoms to which they are attached, form a substituted or unsubstituted C₃₋₆ cycloalkyl, or two groups R⁴ together with the non-adjacent carbon atoms to which they are attached form a substituted or unsubstituted 4-7 membered heterocyclyl; X is N; L is -O (C₁₋₆ alkyl) - or - (C₁₋₉ alkyl) -; n is 0-4; m is 0-8; V is a compound of formula (2), where A is N, CH or CRA; B is N, CH, or CRB; each RA is independently selected from halogen, C₁₋₆ substituted or unsubstituted alkyl, and C₃₋₆ substituted or unsubstituted cycloalkyl; each RB is independently selected from halogen and C₁₋₆ substituted or unsubstituted alkyl; RC is halogen or CF₃; R⁵ and R⁶ are C₁₋₃ alkyl, or R⁵ and R⁶, together with the carbon atom to which they are attached, form a C₃₋₆ substituted or unsubstituted cycloalkyl or 3-6 membered heterocyclyl; a is 0-3; and b is 0 - 2. |