| abstract |
Neurosteroid derived compounds, such as ganaxolone and allopregnanolone derivatives, which have improved solubility and bioavailability. Compounds derived from neurosteroids are characterized by formulas (1) and (2), where R¹ is methyl or hydrogen, R² is an ester function (RC (O) O-), R³ is hydrogen, R⁴ is hydrogen a or b, R⁵ is R-CO- or any hydrocarbon structure (R-), and wherein R (in R² or R⁵) is independently selected from any structure comprising 10 carbon atoms or less, which is linear or branched, saturated or unsaturated, that can comprise cyclic or aromatic functions within the structure, and where R does not contain more than 1 OH or NR₂, or 2 ether or thioether functions. |