http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-115877-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5786c4ecd7567fbe5b850ea9add41e46 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23V2002-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23K50-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23L29-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23K20-189 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23L33-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23K50-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23K10-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23L33-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23K50-75 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23K20-189 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-14 |
| filingDate | 2019-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41faa4762abb7503618bb693e912e752 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a144eee54bf8d914e6109a12a7b82b9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_48281bfa2c1654c5d76fa51f0837bb46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1ef3599d8e7c43f9c0ff81972ee189f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_85914dec369d3d9fa528fdb241b83ea5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cfa523e273a5232a06e8b414548aff9c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5dc0e02eff0cf0aeabbfa21dede11a0c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f31fbadbbfa706c1260c4ad900f22a4b |
| publicationDate | 2021-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-115877-A1 |
| titleOfInvention | MEANS AND METHODS FOR CLEARING ZEARALENONE |
| abstract | The present relates to a method of increasing the stability of an a / b-hydrolase. Furthermore, the present relates to an a / b-hydrolase obtainable by the present method. Also provided are a / b-hydrolases that have a decreased grand mean hydropathy (GRAVY) value and / or that comprise specific mutations. Furthermore, the present relates to the use of an a / b-hydrolase herein to degrade zearalenone (ZEN). Claim 1: A method for increasing the stability of an a / b-hydrolase, the a / b-hydrolase comprising a sequence corresponding to positions 145 to 218 of SEQ ID No. 1 or a sequence having 58% or more of sequence identity with a sequence corresponding to positions 145 to 218 of SEQ ID No. 1, which comprises substituting at least one amino acid in a position corresponding to a position 160 to 205 of SEQ ID No. 1 or in a position corresponding to position 159 to 204 of SEQ ID No. 2, or in a position corresponding to a position 160 to 205 of SEQ ID No. 3, 4, or 5, or in a position corresponding to a position 176 to 222 of SEQ ID No. 6, wherein the Amino acid (s) are substituted with an amino acid, which has a more negative hydropathy index than the substituted amino acid, where the hydropathy index is determined by the Kyte and Doolittle hydropathy index , thereby obtaining an a / b-hydrolase with increased stability ntada. Claim 7: An a / b-hydrolase obtainable by the method of any one of claims 4, 5 or 6. Claim 13: A composition comprising an a / b-hydrolase of any one of the preceding claims, preferably the composition is a food or feed additive or a food or feed product. Claim 15: Kit comprising the a / b-hydrolase or the composition of any one of the preceding claims. |
| priorityDate | 2018-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID419521059 http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID5281576 |
Total number of triples: 32.