http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-115228-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f9a36328274867f46f8fc1fb9c868703 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-404 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-404 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-00 |
| filingDate | 2019-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_270b8671d5ce0ae85e7d87c9cc90a5cc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dafb7b14baa379b439e10a157170a44a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c152e294501cf0868f414c22ec3de0d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5695eb29a5657361f40cb2545bf894bd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0daa96b06c394c53bdc37ed8a007fbd5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af2bb307f6cdea927f6e18020809d552 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9ce74863ce309184276434904cc9fe86 |
| publicationDate | 2020-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-115228-A1 |
| titleOfInvention | SUBSTITUTE (AZA) INDOLE DERIVATIVES, A METHOD FOR ITS PREPARATION, INTERMEDIARIES FOR THEIR SYNTHESIS, COMPOSITION AND PHARMACEUTICAL COMBINATION THAT INCLUDE THEM AND THE USE OF THE SAME IN THE TREATMENT OF DISEASES ASSOCIATED WITH THE NICOTINN ACETILCHINE 7 RECEPTOR |
| abstract | Substituted (aza) indole derivatives, a method of obtaining them, intermediates for their preparation and pharmaceutical compositions that comprise it as an active principle. Said compounds are used for the treatment of diseases associated with the activity of the nicotinic acetylcholine receptor α7. Claim 1: A compound characterized in that it is of formula (1), where R¹ is hydrogen or C₁₋₆alkyl; R² is hydrogen or C₁₋₆alkyl, or R² is absent when n is 0; R³ is hydrogen or O; or R³ is absent when m is 0; R⁴ and R⁵ are independently hydrogen, C₁₋₆alkyl, halogen, haloC₁₋₆alkyl, C₁₋₆alkoxy, or CN; n and m are independently 0 or 1, provided that n and m cannot be 0 at the same time; k and l are independently 1, 2 or 3; Y is N or C (R⁶); R⁶ is hydrogen, C₁₋₆alkyl, halogen, or haloC₁₋₆alkyl; R⁷ is hydrogen, C₁₋₆alkyl, or halogen; W is CH or N; Z is CH, C-C₁₋₃alkyl or N; L is an optionally substituted linker consisting of 1, 2 or 3 atoms, represented by T-U-V, where T is CH₂, C (O), NH, SO₂, or O; U is CH₂, C (O), O, or is absent; and V is CH₂, O or is absent; A is a saturated, unsaturated, or aromatic carbocyclyl, or a saturated, unsaturated, or aromatic heterocyclyl, where the heteroatoms are selected from the group of nitrogen, oxygen, and sulfur; optionally independently substituted with one or more halogen, C₁₋₆alkyl, C₁₋₆alkoxy, haloC₁₋₆alkyl, haloC₁₋₆alkoxy, CN, or benzyl atoms; or pharmaceutically acceptable salts, biologically active metabolites, prodrugs, racemates, enantiomers, diasteromers, solvates, and hydrates thereof. Claim 20: The compound characterized in that it responds to 7-fluoro-1H-indole-5-amine. Claim 21: The compound characterized in that it responds to 3-fluoro-1-methyl-1H-pyrrolo [2,3-b] pyridin-5-amine. Claim 22: The compound characterized in that it responds to 2 - [(azetidin-3-yloxy) methyl] -5- (trifluoromethyl) pyridine. Claim 23: The compound characterized in that it responds to {1,2-dimethyl-1H-pyrrolo [2,3-b] pyridin-5-yl} methanamine. Claim 24: The compound characterized in that it responds to {1,3-dimethyl-1H-pyrrolo [2,3-b] pyridin-5-yl} methanamine. Claim 25: The compound characterized in that it responds to {3-chloro-1-methyl-1H-pyrrolo [2,3-b] pyridin-5-yl} methanamine. Claim 26: The compound characterized in that it responds to {3-bromo-1-methyl-1H-pyrrolo [2,3-b] pyridin-5-yl} methanamine. |
| priorityDate | 2018-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.