| abstract |
Compositions and methods of treating an infection with Flaviviridae, including infection with hepatitis C virus, West Nile virus, yellow fever virus, and a rhinovirus, are provided in a host, including animals and especially humans, using (2 'R) -2'-deoxy-2'-fluoro-2'-C-methyl nucleosides, or a pharmaceutically acceptable salt or prodrug thereof. Claim 1: A (2'R) -2'-deoxy-2'-fluoro-2'-C-methyl nucleoside (bD or bL), or its pharmaceutically acceptable salt, characterized in that it is of formula (1) wherein , the base is a pyrimidine base represented by formula (2); X is O; R¹ is H or a triphosphate; R⁷ is H; R³ is H; and R⁴ is NH₂ or OH, characterized in that it consists of the compounds of the group of formulas (3). |