| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9068aa2001d07c3bea38a89d11626cea |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-622
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-624
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-73
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2878
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2851
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-283 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate |
2019-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a34486f15fa64598cbf57c63e0091b89
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_edf88773cace6ac6a8d3d840e39d3f1c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b0be496dd0081ae8ed1f30ce1feca18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a1238b685ae56c21aefaec03b0c241d6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52080cb8795c47fb6b97be4a36caff56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0be5759480ef8caf9613792e052c2153
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c59d39598f2f63ba47016ba21a2a9af
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2138a5dd7ea0f802271ad6551e3bac80 |
| publicationDate |
2020-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
AR-114544-A1 |
| titleOfInvention |
MULTI-SPECIFIC BINDING PROTEINS BINDING BCMA, NKG2D AND CD16, AND METHODS OF USE |
| abstract |
Multispecific binding proteins that bind to and kill human cancer cells expressing B-cell maturation antigen (BCMA), as well as pharmaceutical compositions and therapeutic methods useful for treating BCMA-expressing cancer. Also multispecific binding proteins that bind to and kill BCMA-expressing human cancer cells, and exhibit high potency and maximum target cell lysis compared to anti-BCMA monoclonal antibodies. Claim 1: A protein characterized in that it comprises: (a) a first antigen-binding site comprising a single-chain variable fragment (scFv) that binds to NKG2D; (b) a second antigen-binding site that binds to B cell maturation antigen (BCMA); and (c) an antibody Fc domain or a portion thereof sufficient to bind CD16, or a third antigen-binding site that binds CD16. |
| priorityDate |
2018-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |