| abstract |
The present disclosure relates to compounds that are capable of inhibiting the mitochondrial pyruvate vehicle and promoting hair growth. The disclosure further relates to methods for promoting hair growth or treating conditions or disorders that affect hair growth, such as baldness or alopecia. Claim 1: A compound of formula (1) or (2), wherein: each A is independently CH, CR⁴, or N; Y is carboxyl, ester, amide, or a moiety of formula (3); Z is CH, CR⁴, or N; R² is CN or carboxyl; R³ is H, aryl, aralkyl, or aralkylacyl, and is optionally substituted with one or more R⁵, where each R⁵ is independently selected from alkyl, alkoxy, or halo; each occurrence of R⁴ is independently alkyl, carboxyl, halo, hydroxy, ester, or CN; R⁷ is hydrogen, alkyl, halo, hydroxy, alkoxy, or acyloxy; R¹⁰ is hydrogen or alkyl; and n is 0-4; or a pharmaceutically acceptable salt thereof. |