http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-113880-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9f572e7d4273008fb17b6cea1c70aac2 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C68-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C69-96 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-0012 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-724 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-724 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H3-06 |
| filingDate | 2018-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-113880-A1 |
| titleOfInvention | INDUSTRIAL PROCESS TO PREPARE 6-PERDESOXY-6-PER (2-CARBOXYETHYL) THIO-g-CYCLODEXTRIN (SUGAMMADEX SODIUM) SODIUM SALT |
| abstract | An industrial process to prepare the sodium salt of 6-perdeoxy-6-per (2-carboxyethyl) thio-g-cyclodextrin (Sugammadex sodium), comprising: a) reacting g-cyclodextrin with triphosgene in the presence of dimethylformamide (DMF) to obtain the intermediate compound 6-perdeoxy-6-perchloro-g-cyclodextrin; and b) reacting the intermediate compound 6-perdeoxy-6-perchloro-g-cyclodextrin with 3-mercaptopropionic acid in the presence of the sodium hydroxide base to obtain crude Sugammadex sodium. As an accessory, the obtained crude 6-perdeoxy-6-perchloro-g-cyclodextrin intermediate is purified. Additionally, the process comprises step c) of purifying the crude Sugammadex sodium by recrystallization to obtain pure Sugammadex sodium. The Sugammadex sodium obtained has a purity of the order of 96-98%. |
| priorityDate | 2018-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.