| abstract |
The present provides heterocyclic compounds having the general formula (1) wherein A, L, X, Y, m, n, R¹ and R² are as described herein, compositions including the compounds, processes for making the compounds and methods for using the compounds. Claim 1: A compound of formula (1), wherein X is CH or N and L is -C (R³R⁴) - or a covalent bond; or X is C (sp²) and together with L forms a group of formula (2), where the asterisk indicates the point of attachment to ring A; Y is CH₂ or O; n and m are independently 0, 1 or 2; A is selected from the group consisting of (i) aryl substituted with R⁵, R⁶, and R⁷; and (ii) heteroaryl substituted with R⁸, R⁹, and R¹⁰; R¹ and R² are each independently selected from the group consisting of hydrogen, halogen, alkoxy, and haloalkoxy; R³ is selected from the group consisting of (i) aryl substituted with R¹¹ and R¹², (ii) heteroaryl substituted with R¹³ and R¹⁴, (iii) cycloalkyl substituted with R¹⁵ and R¹⁶; and (iv) heterocyclyl substituted with R¹⁷ and R¹⁸; R⁴ is hydrogen or hydroxy; or R³ and R⁴ together with the carbon atom to which they are attached form a heterocycle or a carbocycle; and R⁵, R⁶, R⁷, R⁸, R⁹, R¹⁰, R¹¹, R¹², R¹³, R¹⁴, R¹⁵, R¹⁶, R¹⁷, and R¹⁸ are each independently selected from the group consisting of hydrogen, halogen, alkyl, haloalkyl, hydroxyalkyl, alkoxy , haloalkoxy, haloalkoxyalkoxy, aryl, cycloalkyl, haloaryl, haloarylalkyl, alkylsulfonyl, oxo, and a fluorescent marker; or a pharmaceutically acceptable salt thereof. |