| abstract |
In the present description a pharmaceutical composition is provided comprising two, three or four compounds, wherein each compound is independently a phosphodiesterase inhibitor, an adenosine receptor antagonist, a calcium channel blocker, a histamine H receptor agonist. , a histamine H₂ receptor agonist, a histamine H₃ receptor antagonist, or a b₂ adrenergic receptor agonist. Further provided herein is the pharmaceutical composition used to treat or ameliorate a cardiovascular disease in a subject, comprising administering to the subject in need of these two, three or four compounds, wherein each compound is independently a phosphodiesterase inhibitor, an adenosine receptor antagonist, a calcium channel blocker, a histamine H₁ receptor agonist, a histamine H₂ receptor agonist, a histamine H₃ receptor antagonist, or a b₂ adrenergic receptor agonist. |