http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-113258-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f7ddc4774cf5f8a0bda44a780d73c53d |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-605 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-605 |
| filingDate | 2018-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20b529105aab4c11f5fc8a09ee213ca4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ceba070752048340ff9a5b6d9aadd3d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_690cf824ad030eb757f4f434066c3408 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26b4479599bbbc121aecf68a94facd33 |
| publicationDate | 2020-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-113258-A1 |
| titleOfInvention | PERSISTENT CONJUGATES OF PEPTIDE 2 DERIVATIVES SIMILAR TO GLUCAGON (GLP-2) |
| abstract | This refers to derivatives of glucagon-like peptide 2 (GLP-2), their conjugates and their use. The present also relates to a method for producing a derivative of glucagon-like peptide 2 (GLP-2) and a conjugate thereof. Claim 1: A glucagon-like peptide 2 (GLP-2) conjugate, in which a GLP-2 derivative and an immunoglobulin Fc region are each covalently linked by means of a non-peptidyl polymer at both terminal ends of the non-peptidyl polymer, wherein the non-peptidyl polymer is selected from the group consisting of polyethylene glycol, polypropylene glycol, ethylene glycol-propylene glycol copolymer, polyoxyethylated polyol, polyvinyl alcohol, polysaccharide, dextran, polyvinyl ethyl ether, lipid polymer, chitin, hyaluronic acid a combination of them. Claim 2: The GLP-2 conjugate according to claim 1, wherein the GLP-2 derivative comprises an amino acid sequence of the following general formula (1): X¹X²DGSFSDEMNTILDNLAARDFlNWLlQTX³⁰ITDX³⁴ (SEQ ID No. 9) (1), wherein the above formula, X¹ is histidine, imidazoacetyldesistidine, desaminohistidine, b-hydroxyimidazopropionyldesistidine, N-dimethylhistidine. or b-carboxyimidazopropionyldesistidine; X² is alanine, glycine, or 2-aminoisobutyric acid (Aib); X³⁰ is lysine or arginine; X³⁴ is absent, or lysine, arginine, glutamine, histidine, 6-azido-lysine, or cysteine; provided that any sequence identical to an amino acid sequence of SEQ ID No. 1 in the general formula (1) is excluded. |
| priorityDate | 2017-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 79.