| abstract |
The present relates to a fusion protein between a therapeutic enzyme and an immunoglobulin Fc region, its method, and a composition comprising the fusion protein. Claim 2: The enzyme fusion protein of claim 1, wherein the therapeutic enzyme is selected from the group consisting of b-glucosidase, a-galactosidase, b-galactosidase, iduronidase, iduronate-2-sulfatase, galactose-6 -sulfatase, acid a-glucosidase, acid ceramidase, acid sphingomyelinase, galactocerebrosidase, arylsulfatase A, B, b-hexosaminidase A, B, heparin N-sulfatase, aD-mannosidase, b-glucuronidase, N-acetylgalactosamine-acid 6 Lysosomal, aN-acetyl-glucosaminidase, glucocerebrosidase, butyrylcholinesterase, chitinase, glutamate decarboxylase, imiglucerase, lipase, uricase, platelet activating factor, acetylhydrolase, neutral endopeptidase, and myeloperoxidase. Claim 3: The enzyme fusion protein of claim 1, wherein a therapeutic enzyme and an immunoglobulin Fc region are fused via a peptide linker. |