http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-112478-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_40765ca9a78b54a8a76f781d159ad145 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4985 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-04 |
| filingDate | 2018-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_40c4a921a4b3e7f706dbf0a1e428fd2d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_793ebb970a6654084343c2149266c4c8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2909aed5ddbbdd540956cfdae6fd44d2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d868a79e28cda8557f9f67902f26683e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8fc3e08b268f73c75bf22df4d3d13887 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1de28dcb900eb56a66ced684976f9c4b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8eafd9b93ec6600bf7e3c4551ff18096 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9aac0b3743f12b35905329b7fd754ae7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e30df3bc06847f006cef04c0ab0a73b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad691877ad3667a78fb7dc809484686d |
| publicationDate | 2019-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-112478-A1 |
| titleOfInvention | CONDENSED HETEROCYCLIC COMPOUNDS AS IDO1 INHIBITORS |
| abstract | Compounds with IDO1 inhibitory activity; used in the treatment of cancer. Claim 1: A compound of formula (1), wherein X¹ at each location in formula (1) is independently N, CH, or CXR; X² is N or C, where R² is absent when X² is N; X⁴ at each location in formula (1) is independently N, CH, or CR¹; X⁵ is CH, CXR, or CR¹; XR is hydrogen, halogen, C₁₋₃ haloalkyl, or C₁₋₆ alkyl; R¹ is hydrogen, deuterium, halogen, -CN, -OCF₃, -OCHF₂, or -CF₃, where n is 0 - 5 and where if n is> 1, R¹ can be independently the same or different from each other ; R² is hydrogen, halogen, C₁₋₆ alkyl, or an aryl unsubstituted or substituted with one, two, or three substituents independently selected from halogen, -CN, C₁₋₆ haloalkyl, and C₁₋₆ alkyl; R³ is C₃₋₆ cycloalkyl, C₃₋₆ heterocycle, or mono or bicyclic aryl or heteroaryl, wherein each mono or bicyclic aryl or heteroaryl is unsubstituted or substituted with one, two or three substituents independently selected from halogen, -CN, C₁₋₆ haloalkyl, and C₁₋₆ alkyl; and R⁴ is halogen, C₁₋₆ alkyl, C₁₋₆ haloalkyl, -OCF₃, C₃₋₆ cycloalkyl, or a 4-12 membered heterocycle; or a pharmaceutically acceptable salt thereof. Claim 64: A compound of formula (2), wherein X¹ at each location in formula (2) is independently N, CH or CXR; X² is N or C, where R² is absent when X² is N; X⁴ at each location in formula (2) is independently N, CH, or CR¹; X⁵ is CH, CXR, or CR¹; XR is hydrogen, halogen, C₁₋₃ haloalkyl, or C alqu alkyl; R¹ is hydrogen, deuterium, halogen, -CN, -OCF₃, -OCHF₂ or -CF₃, where n is 0-4 and where if n is> 1, R¹ can be independently the same or different from each other; R² is hydrogen, halogen, C₁₋₆ alkyl, or an aryl unsubstituted or substituted with one, two or three substituents independently selected from halogen, -CN, C₁₋₆ haloalkyl, and C₁₋₆ alkyl; R³ is C₃₋₆ cycloalkyl, C₃₋₆ heterocycle, aryl or mono or bicyclic heteroaryl, wherein each mono or bicyclic aryl or heteroaryl is unsubstituted or is substituted with one, two or three substituents independently selected from halogen, -CN, C₁₋₆ haloalkyl and C₁₋₆ alkyl; and R⁴ is halogen, C₁₋₆ alkyl, C₁₋₆ haloalkyl, -OCF₃, C₃₋₆ cycloalkyl, or a 4-12 membered heterocycle; or a pharmaceutically acceptable salt thereof. |
| priorityDate | 2017-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.