| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8638cb72aeea650dceba24d2fefdbb0b |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-815
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-43559
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-0003 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-67
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P33-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-80
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-002
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-569
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-81 |
| filingDate |
2018-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b95b7a04d62d00c7d7a59ff86d2c2d8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a3376bff15d9b92b09980baf481e86a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ff659abdbb5916fd0eb4a9e191f1439 |
| publicationDate |
2019-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
AR-111507-A1 |
| titleOfInvention |
RECOMBINANT VACCINE AGAINST HELMINTOS PRODUCED IN PICHIA PASTORIS AND PROTEIN PRODUCTION AND PURIFICATION PROCESSES AS A VACCINE AGAINST HELMINTOS |
| abstract |
This is related to the production of proteins in recombinant form using a synthetic gene for high protein expression in Pichia pastoris. Specifically, the production of the Schistosoma mansoni Sm14 protein is described in recombinant form, where a synthetic gene was created for the high expression of this protein, and with it cloning was obtained under control of two types of Pichia pastoris promoters: inducible promoter by methanol (AOX1) and constitutive promoter (GAP). With these constructions, Pichia pastoris strains were genetically manipulated to effectively produce the Sm14 vaccine antigen. The process of production and purification of this protein from P. pastoris cells was also perfected, and may be available for production on an industrial scale. |
| priorityDate |
2017-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |