http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-111367-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c7ad58d3c0b071069a8ee0cb8c8ba2e8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f52c68e4149a6c462b850d4e7cc2b2f9 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D451-02 |
| filingDate | 2018-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_747329963d8897a704469b0cefe2c8b4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b24e07d7301984ddd669aca56d72cf3f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b678c9b75e3d12b96c709ddb7d786527 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1865bb8ba4b0c42302a37dde2ce63819 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_88c5c25482abe094c20bc2b125b0d8b3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_085f2fb6b58f0cf3d2080c5ad4bdc19b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ffbfd6f3b4fa45bfa83597cb1b86329 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_91844aff65e6756022fb1ec390bfd645 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_23c810e025c7615bfc2a8dc71f59261a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d6a299eeafafeb4b912961e27158e08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_64c0031465c70eb3395dfb9b9c94e129 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_458a922363cf48a79f1a6886b9c8ed16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da910ad494e69eac93e584c729ef868d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9c6b6d3965f6e663cfddb102b514cec5 |
| publicationDate | 2019-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-111367-A1 |
| titleOfInvention | N-ARILETIL-2-AMINOQUINOLIN-4-SUBSTITUTED CARBOXAMIDS AND THEIR USE |
| abstract | Claim 1: Compounds of the formula (1), characterized in that Ar represents phenyl or pyridyl, where phenyl can be up to tetrasubstituted and pyridyl until disubstituted, in each case the same or different, with fluorine, chlorine, with C₁₋₄ alkyl up to trisubstituted with fluorine, with C₃₋₄ cycloalkyl until tetrasubstituted with fluorine, with C₁₋₂ alkoxy to trisubstituted with fluorine, or with C₁₋₂ alkylsulfanyl until trisubstituted with fluorine, or where two substituents of the phenyl or pyridyl group, if attached to atoms adjacent rings, if necessary, are joined in such a way that together they form a methylenedioxy- or ethylenedioxy group, or where phenyl can be substituted up to five times with fluorine; Y represents a union or a group of the formula: # ¹-X- (CR¹⁰AR¹⁰B) ₖ- # ², where # ¹ represents the point of union with the carbon atom; #² represents the point of attachment with the carboxy group; X represents a union, -CH₂-, -O-, -S (= O) ₘ- or -N (R¹¹) -, in which m means 0, 1 or 2, and R¹¹ means hydrogen or methyl; R¹⁰A and R¹⁰B independently of each other represent hydrogen, fluorine or methyl, or R¹⁰A and R¹⁰B together with the carbon atom to which they are attached, a cyclopropyl group; k represents 1, 2, 3 or 4; R¹ represents halogen, C₁₋₄ alkyl substituted up to five times with fluorine, methoxy to trisubstituted with fluorine, (trifluoromethyl) sulfanyl, pentafluorosulfanyl, trimethylsilyl, ethynyl, cyclopropyl, or cyclobutyl, where cyclopropyl and cyclobutyl can be substituted up to four times with fluorine; R², R³ and R⁴ independently of each other represent hydrogen, halogen or methyl until trisubstituted with fluorine; R⁵ represents halogen, C₁₋₄ alkyl substituted up to five times with fluorine, methoxy to trisubstituted with fluorine, hydroxy, methylsulfanyl, (trifluoromethyl) sulfanyl, cyano, ethenyl, cyclopropyl or cyclobutyl, where cyclopropyl and cyclobutyl can be substituted up to four times with fluorine ; R⁶ represents -NR¹²R¹³, where R¹² means hydrogen or C₁₋₃ alkyl, and R¹³ means C₁₋₄ alkyl or C₃₋₇ cycloalkyl, where C₃₋₇ cycloalkyl can be substituted up to four times with fluorine and C₁₋₄ alkyl can be substituted up to five times with fluorine or be mono-substituted with C₃₋₆ cycloalkyl, methoxy, trifluoromethoxy or phenyl, where phenyl can be up to trisubstituted with fluorine, or represents a 6 to 10 membered bicyclic heterocycle, 4 to 8 membered monocyclic, saturated or partially unsaturated , joined by means of a nitrogen atom, which may contain an additional heteroatom, equal or different from the N, O, S, SO or SO₂ series as an annular member, where the 6 to 10 membered bicyclic heterocycle, monocyclic 4 to 8 members may be substituted in each case with 1 to 3 substituents independently selected from the group C₁₋₄ alkyl, hydroxy, oxo, C₁₋₃ alkoxy, difluoromethoxy, trifluoromethoxy, cyano, amino, monomethylamino, dimethylamino, aminocarbonyl, monomethylaminocarbonyl, dimethylaminocarbonyl and can also be substituted up to four times with fluorine, where C₁₋₄ alkyl can be substituted up to five times with fluorine or be monosubstituted with hydroxy or methoxy; R⁷A and R⁷B independently of each other represent hydrogen or methyl, or R⁷A and R⁷B together with the carbon atom to which they are attached, a cyclopropyl group; R⁸ represents hydrogen, fluorine, methyl, trifluoromethyl, ethyl or hydroxy; R⁹ represents hydrogen or methyl; as well as its N-oxides, salts, solvates, salts of the N-oxides and solvates of the N-oxides and salts. |
| priorityDate | 2017-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 78.