| abstract |
A method of treating or ameliorating a syndrome, disorder, or disease, wherein the syndrome, disorder, or disease is rheumatoid arthritis or psoriasis. A method for modulating RORgt activity in a mammal by administering a therapeutically effective amount of at least one compound according to claim 1. Claim 1: A method for preparing a 5-(2,3-dichloro- 4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-(2-hydroxy-2-methylpropyl)-4-(R¹-1-carbonyl)thiazole -2-carboxamide of formula (1) comprising the step of reacting R¹-H with 5-(2,3-dichloro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropane acid -2-yl)phenyl)-2-((2-hydroxy-2-methylpropyl)carbamoyl)thiazole-4-carboxylic acid of formula (2) in the presence of N,N-diisopropylethylamine and O-(7-azabenzotriazole- hexafluorophosphate 1-yl)-N,N,N',N'-tetramethyluronium, as shown in the reaction; wherein R¹ is selected from the group consisting of the residues of the group of formulas (3). |