| abstract |
This refers to a compound of formula (1), in which: R¹ is hydrogen, lower alkyl, lower alkyl substituted by halogen, halogen, lower alkoxy or lower alkoxy substituted by halogen, R¹ may be the same or different in the case that n = 2 or 3; n is 1, 2 or 3; m is 1, 2 or 3; Ar is a five or six element heteroaryl group, selected from among the compounds of the group of formulas (2), in which: R² is hydrogen, lower alkyl, lower alkyl substituted by halogen, halogen or lower alkoxy; R³ is hydrogen or halogen; - () ₘ- is - (CH₂) ₘ-; or to pharmaceutically active acid addition salts thereof. The compounds can be used for the treatment of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with Dutch amyloidosis (HCHWA-D), multi-infarcted dementia, pugilistic dementia or Down syndrome. |