http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-108501-A2
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3a97397211794e21707a376cc9eda4d0 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4985 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
filingDate | 2017-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2018-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | AR-108501-A2 |
titleOfInvention | IMIDAZO COMPOUND [4,5-B] REPLACED PIRAZIN-2-OL OR A COMPOSITE OF 1H-IMIDAZO [4,5-B] PIRAZIN-2 (3H) -REPLACED AREA, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND ITS USE TO PREPARE A MEDICINAL PRODUCT |
abstract | Certain chemical entities and methods of use are provided for modulating skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C. Skeletal troponin I, skeletal troponin T, and skeletal muscle including fragments and isoforms thereof, as well as skeletal sarcomere, and methods of use in the treatment of obesity, sarcopenia, wasting syndrome, weakness, cachexia, muscle spasms muscle weakness after a surgical and post-traumatic operation, neuromuscular disease and other indications. Claim 1: A substituted imidazo [4,5-b] pyrazin-2-ol compound or a 1H-imidazo [4,5-b] pyrazin-2 (3H) -one substituted compound, characterized in that it is selected from: 6- (1H-1,2,3-triazol-4-yl) -1- (ethylpropyl) imidazo [4,5-b] pyrazin-2-ol; (E) -1-cyclopropyl-6- (prop-1-enyl) -1H-imidazo [4,5-b] pyrazin-2-ol; (E) -6- (prop-1-enyl) -1- (tetrahydro-2H-piran-4-yl) -1H-imidazo [4,5-b] pyrazin-2-ol; (S) - (2-Hydroxy-1- (1-phenylethyl) -1H-imidazo [4,5-b] pyrazin-6-yl) (4-methylpiperazin-1-yl) methanone; (S) - (2-Hydroxy-1- (1-phenylethyl) -1H-imidazo [4,5-b] pyrazin-6-yl) (morpholino) methanone; (S) - (2-Hydroxy-1- (1-phenylethyl) -1H-imidazo [4,5-b] pyrazin-6-yl) (piperidin-1-yl) methanone; (S) -1- (1-phenylethyl) -1H-imidazo [4,5-b] pyrazin-2-ol; (S) -1- (1-phenylethyl) -1H-imidazo [4,5-b] quinoxalin-2-ol; (S) -1- (1-phenylethyl) -6- (piperidin-1-ylmethyl) -1H-imidazo [4,5-b] pyrazin-2-ol; (S) -1- (2-hydroxy-1- (1-phenylethyl) -1H-imidazo [4,5-b] pyrazin-6-yl) ethanone; (S) -2-hydroxy-1- (1-phenylethyl) -1H-imidazo [4,5-b] pyrazine-6-carbonitrile; (S) -2-hydroxy-1- (1-phenylethyl) -1H-imidazo [4,5-b] pyrazine-6-carboxamide; (S) -2-hydroxy-1- (1-phenylethyl) -1H-imidazo [4,5-b] pyrazine-6-carboxylic acid; (S) -2-hydroxy-N, N-dimethyl-1- (1-phenylethyl) -1H-imidazo [4,5-b] pyrazine-6-carboxamide; (S) -2-hydroxy-N-methyl-1- (1-phenylethyl) -1H-imidazo [4,5-b] pyrazine-6-carboxamide; (S) -6 - ((4-methylpiperazin-1-yl) methyl) -1- (1-phenylethyl) -1H-imidazo [4,5-b] pyrazin-2-ol; (S) -6 - ((dimethylamino) methyl) -1- (1-phenylethyl) -1H-imidazo [4,5-b] pyrazin-2-ol; (S) -6- (2-hydroxypropan-2-yl) -1- (1-phenylethyl) -1H-imidazo [4,5-b] pyrazin-2-ol; (S) -6- (methylsulfonyl) -1- (1-phenylethyl) -1H-imidazo [4,5-b] pyrazin-2-ol; (S) -6- (morpholinomethyl) -1- (1-phenylethyl) -1H-imidazo [4,5-b] pyrazin-2-ol; (S) -6-cyclohexyl-1- (1-phenylethyl) -1H-imidazo [4,5-b] pyrazin-2-ol; (S) -6-Hexyl-1- (1-phenylethyl) -1H-imidazo [4,5-b] pyrazin-2-ol; (S) -6-Isobutyl-1- (1-phenylethyl) -1H-imidazo [4,5-b] pyrazin-2-ol; (S) -methyl-2-hydroxy-1- (1-phenylethyl) -1H-imidazo [4,5-b] pyrazine-6-carboxylate; (S) -N, N-diethyl-2-hydroxy-1- (1-phenylethyl) -1H-imidazo [4,5-b] pyrazine-6-carboxamide; (S) -N-Benzyl-2-hydroxy-1- (1-phenylethyl) -1H-imidazo [4,5-b] pyrazine-6-carboxamide; (Z) -1-cyclopropyl-6- (prop-1-enyl) -1H-imidazo [4,5-b] pyrazin-2-ol; (Z) -6- (prop-1-enyl) -1- (tetrahydro-2H-piran-4-yl) -1H-imidazo [4,5-b] pyrazin-2-ol; 1- (2-hydroxy-1- (pentan-3-yl) -1 H -imidazo [4,5-b] pyrazin-5-yl) ethanone; 1- (pentan-3-yl) -5-vinyl-1H-imidazo [4,5-b] pyrazin-2-ol; 1-benzyl-6-bromo-1H-imidazo [4,5-b] pyrazin-2-ol; 1-cyclopropyl-6- (methylthio) -1H-imidazo [4,5-b] pyrazin-2-ol; 2- (6-Bromo-2-hydroxy-1H-imidazo [4,5-b] pyrazin-1-yl) propane-1,3-diol; 2-hydroxy-1- (pentan-3-yl) -1 H -imidazo [4,5-b] pyrazine-5-carboxylic acid; 2-hydroxy-N, N-dimethyl-1- (pentan-3-yl) -1 H -imidazo [4,5-b] pyrazine-5-carboxamide; 2-hydroxy-N-methyl-1- (pentan-3-yl) -1H-imidazo [4,5-b] pyrazine-5-carboxamide; 5- (methylthio) -1- (pentan-3-yl) -1H-imidazo [4,5b] pyrazin-2-ol; 5-ethyl-1- (pentan-3-yl) -1H-imidazo [4,5-b] pyrazin-2-ol; 6- (methylsulfinyl) -1 - ((S) -1-phenylethyl) -1H-imidazo [4,5-b] pyrazin-2-ol; 6- (methylthio) -1- (tetrahydro-2H-pyran-4-yl) -1H-imidazo [4,5-b] pyrazin-2-ol; 6-Bromo-1- (2-morpholinoethyl) -1H-imidazo [4,5-b] pyrazin-2-ol; 6-Bromo-1- (tetrahydro-2H-piran-4-yl) -1H-imidazo [4,5-b] pyrazin-2-ol; 6-Bromo-1-cyclopropyl-1H-imidazo [4,5-b] pyrazin-2-ol; 6-cyclopropyl-1- (pentan-3-yl) -1H-imidazo [4,5-b] pyrazin-2-ol; 6-ethynyl-1- (pentan-3-yl) -1H-imidazo [4,5-b] pyrazin-2-ol; Methyl 2-hydroxy-1- (pentan-3-yl) -1 H -imidazo [4,5-b] pyrazine-5-carboxylate; 6- (dimethylamino) -1- (ethylpropyl) imidazo [4,5-] pyrazin-2-ol; 6-ethynyl-1- (pentan-3-yl) -1H-imidazo [4,5-b] pyrazin-2 (3H) -one; 1- (pentan-3-yl) -6- (1 H-1,2,3-triazol-4-yl) -1 H -imidazo [4,5-b] pyrazin-2 (3 H) -one; (E) -1-cyclopropyl-6- (prop-1-enyl) -1H-imidazo [4,5-b] pyrazin-2 (3H) -one; (E) -6- (prop-1-enyl) -1- (tetrahydro-2H-pyran-4-yl) -1H-imidazo [4,5-b] pyrazin-2 (3H) -one; (S) -1- (1-phenylethyl) -1H-imidazo [4,5-b] pyrazin-2 (3H) one; (S) -1- (1-phenylethyl) -1H-imidazo [4,5-b] quinoxalin-2 (3H) one; (S) -1- (1-phenylethyl-6- (piperidin-1-ylmethyl) -1H-imidazo [4,5-b] pyrazin-2 (3H) -one; (S) -1- (1-phenylethyl ) -6- (piperidine-1-carbonyl) -1H-imidazo [4,5-b] pyrazin-2 (3H) -one; (S) -2-oxo-3- (1-phenylethyl) -2,3 -dihydro-1H-imidazo [4,5-b] pyrazine-5-carbonitrile; (S) -2-oxo-3- (1-phenylethyl) -2,3-dihydro-1H-imidazo [4,5-b ] pyrazine-5-carboxamide; (S) -2-oxo-3- (1-phenylethyl) -2,3-dihydro-1H-imidazo [4,5-b] pyrazine-5-carboxylic acid; (S) - 6 - ((4-methylpiperazin-1-yl) methyl) -1- (1-phenylethyl) -1H-imidazo [4,5-b] pyrazin-2 (3H) -one; (S) -6 - (( dimethylamino) methyl) -1- (1-phenylethyl) -1H-imidazo [4,5-b] pyrazin-2 (3H) -one; (S) -6- (2-hydroxypropan-2-yl) -1- (1-phenylethyl) -1H-imidazo [4,5-b] pyrazin-2 (3H) -one; (S) -6- (4-methylpiperazine-1-carbonyl) -1- (1-phenylethyl) -1H -imidazo [4,5-b] pyrazin-2 (3H) -one; (S) -6- (methylsulfonyl) -1- (1-phenylethyl) -1H-imidazo [4,5-b] pyrazin-2 ( 3H) -one; (S) -6- (morpholino-4-carbonyl) -1- (1-phenylethyl) -1H-imidazo [4,5-b] pyrazin-2 (3H) -one; (S) - 6- (morpholinomethyl) -1- (1-phenylethyl) -1H-imidazo [4,5-b] pyrazin-2 (3H) -one; (S) -6-acetyl-1- (1-phenyle til) -1H-imidazo [4,5-b] pyrazin-2 (3H) -one; (S) -6-cyclohexyl-1- (1-phenylethyl) -1H-imidazo [4,5-b] pyrazin-2 (3H) -one; (S) -6-Hexyl-1- (1-phenylethyl) -1H-imidazo [4,5-b] pyrazin-2 (3H) -one; (S) -6-Isobutyl-1- (1-phenylethyl) -1H-imidazo [4,5-b] pyrazin-2 (3H) -one; (S) -methyl-2-oxo-3- (1-phenylethyl) -2,3-dihydro-1H-imidazo [4,5-b] pyrazine-5-carboxylate; (S) -N, N-diethyl-2-oxo-3- (1-phenylethyl) -2,3-dihydro-1 H -imidazo [4,5-b] pyrazin-5-carboxamide; (S) -N, N-dimethyl-2-oxo-3- (1-phenylethyl) -2,3-dihydro-1 H -imidazo [4,5-b] pyrazine-5-carboxamide; (S) -N-Benzyl-2-oxo-3- (1-phenylethyl) -2,3-dihydro-1 H -imidazo [4,5-b] pyrazine-5-carboxamide; (S) -N-methyl-2-oxo-3- (1-phenylethyl) -2,3-dihydro-1 H -imidazo [4,5-b] pyrazine-5-carboxamide; (Z) -1-cyclopropyl-6- (prop-1-enyl) -1H-imidazo [4,5-b] pyrazin-2 (3H) -one; (Z) -6- (prop-1-enyl) -1- (tetrahydro-2H-pyran-4-yl) -1H-imidazo [4,5-b] pyrazin-2 (3H) -one; 1- (pentan-3-yl) -5-vinyl-1H-imidazo [4,5-b] pyrazin-2 (3H) -one; 1-benzyl-6-bromo-1H-imidazo [4,5-b] pyrazin-2 (3H) -one; 1-cyclopropyl-6- (methylthio) -1H-imidazo [4,5-b] pyrazin-2 (3H) -one; 2-oxo-1- (pentan-3-yl) -2,3-dihydro-1H-imidazo [4,5-b] pyrazine-5-carboxylic acid; 5- (methylthio) -1- (pentan-3-yl) -1H-imidazo [4,5-b] pyrazin-2 (3H) -one; 5-acetyl-1- (pentan-3-yl) -1H-imidazo [4,5-b] pyrazin-2 (3H) -one; 5-ethyl-1- (pentan-3-yl) -1H-imidazo [4,5-b] pyrazin-2 (3H) -one; 6- (methylsulfinyl) -1 - ((S) -1-phenylethyl) -1H-imidazo [4,5-b] pyrazin-2 (3H) -one; 6- (methylthio) -1- (tetrahydro-2H-pyran-4-yl) -1H-imidazo [4,5-b] pyrazin-2 (3H) -one; 6-Bromo-1- (1,3-dihydroxypropan-2-yl) -1 H -imidazo [4,5-b] pyrazin-2 (3 H) -one; 6-Bromo-1- (2-morpholinoethyl) -1H-imidazo [4,5-b] pyrazin-2 (3H) -one; 6-Bromo-1- (tetrahydro-2H-piran-4-yl) -1H-imidazo [4,5-b] pyrazin-2 (3H) -one; 6-Bromo-1-cyclopropyl-1H-imidazo [4,5-b] pyrazin-2 (3H) -one; 6-cyclopropyl-1- (pentan-3-yl) -1 H -imidazo [4,5-b] pyrazin-2 (3 H) -one; Methyl 2-oxo-1- (pentan-3-yl) -2,3-dihydro-1H-imidazo [4,5-b] pyrazine-5-carboxylate; N, N-dimethyl-2-oxo-1- (pentan-3-yl) -2,3-dihydro-1 H -imidazo [4,5-b] pyrazine-5-carboxamide; N-methyl-2-oxo-1- (pentan-3-yl) -2,3-dihydro-1H-imidazo [4,5-b] pyrazine-5-carboxamide; and 6- (diethylamino) -1- (pentan-3-yl) -1H-imidazo [4,5-b] pyrazin-2 (3H) -one. |
priorityDate | 2006-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
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