http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-107974-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7064 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7064 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-213 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-207 |
| filingDate | 2017-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e0b49ff0a6eaa938590a54eb517bdf9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6218503f03b5a29279b094f321a789f5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_122071084830f29836d0e7da23fdc8fc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f9aed4ebcbbb4c21dfe99393beea7f2f |
| publicationDate | 2018-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-107974-A1 |
| titleOfInvention | ALKIN NUCLEOSID ANALOGS AS HUMAN RINOVIRUS INHIBITORS |
| abstract | It further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent, and methods for using the compounds and compositions for the treatment of viral infections, especially HRV. Claim 1: A compound of formula (1), wherein: R¹ is H, Me, Et, iPr, or cyclopropyl; R² is H, phosphate, diphosphate, triphosphate, -P (= X) (OR⁴) ₂, -P (= X) (OR⁴) (NR⁵R⁶), or -P (= X) (NR⁵R⁶) ₂, and R³ is H or -C (O) R; or R³ and R² taken together form -P (= X) (OR⁴) - or -P (= X) (NR⁵R⁶) -; X at each occurrence is independently O or S; R⁴ is selected from H, phenyl optionally substituted with one or two groups selected from list A, and C₁₋₄ alkyl optionally substituted with one or two groups selected from halo, -OR, -OC (O) R, -OC (O ) -OR, -NR₂, C (O) R, COOR and -C (O) NR₂; each R⁵ is independently H, -C (O) R, COOR, or C₁₋₄ alkyl optionally substituted with OH, amino, or COOR; each R⁶ is independently selected from H, phenyl optionally substituted with one or two groups selected from list A, and C₁₋₄ alkyl optionally substituted with one or two groups selected from list B; each R is independently H or a C₁₋₄ alkyl group optionally substituted with one to three groups selected from halo, hydroxy, CN, amino, C₁₋₃ alkoxy, -C (O) R⁷, -OC (O) R⁷, -C (O) -OR⁷, or -OC (O) -OR⁷; R⁷ is selected from H, C₁₋₄ alkyl optionally substituted with one to three groups selected from halo, hydroxy, CN, amino, and C₁₋₃ alkoxy, or phenyl optionally substituted with one or two groups selected from list A; List A is halo, hydroxy, -NO₂, CN, -OR⁸, -OC (O) R⁸, -OC (O) -OR⁸, -N (R⁸) ₂, -C (O) R⁸, COOR⁸, -C ( O) N (R⁸) ₂, and C₁₋₃ alkyl optionally substituted with one to three groups selected from halo, hydroxy, CN, amino, and C₁₋₃ alkoxy; List B is halo, hydroxy, oxo, CN, -OR⁸, -OC (O) R⁸, -OC (O) -OR⁸, -N (R⁸) ₂, -C (O) R⁸, COOR⁸ and -C (O ) N (R⁸) ₂; and R⁸ is independently in each case selected from H and C₁₋₄ alkyl optionally substituted with one to three groups selected from halo, hydroxy, CN, amino and C₁₋₃ alkoxy, and two R⁸ attached to the same nitrogen atom can optionally be cycled to forming a 3-7 membered heterocycle, optionally containing an additional N, O or S as a ring member, and may be substituted by one or two groups selected from oxo, halo, -OH, amino, C₁₋₃ alkyl, alkoxy C₁₋₃, and haloalkyl C₁₋₃; or a pharmaceutically acceptable salt thereof. |
| priorityDate | 2016-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 37.