| abstract |
Claim 1: Compounds of the formula (1), in which X¹, X², X³, X⁴ each independently denotes CH or N; Y denotes N or CH; Q denotes H or CH₃; R¹ denotes H, F, Cl, Br, CN, CH₃, CF₃ or OCH₃; R² denotes H, F or Cl; R³ denotes phenyl, naphthyl, pyridyl, pyrimidinyl, quinolinyl, isoquinolinyl, indolyl, indazolyl, thiophenyl, dihydroisoindolyl or benzimidazolyl, each of which is unsubstituted or substituted once, twice or three times with Hal, CN, NO₂, A, (CR⁴)ₙOR⁴, (CR⁴)ₙN(R⁴)₂, (CR⁴)ₙS(O)ₘR⁴, (CR⁴)ₙCON(R⁴)₂, (CR⁴)ₙCOHet, (CR⁴)ₙSO₂N(R⁴)₂, (CR⁴)ₙSO₂Het , (CR⁴)ₙN(R⁴)₂, (CR⁴)ₙHet, O(CR⁴)ₙCOHet, (CR⁴)ₙO(CR⁴)ₙHet, (CR⁴)ₙN(R⁴)(CR⁴)ₙHet, (CR⁴)ₙCON(R⁴)( CR⁴)ₙHet, (CR⁴)ₙCON(R⁴)(CR⁴)ₙN(R⁴)₂, (CR⁴)ₙN(R⁴)COA, (CR⁴)ₙN(R⁴)COHet’, (CR⁴)ₙOCyc and/or (CR⁴)ₙCOOR⁴ ; R⁴ denotes H or A'; A denotes unbranched or branched alkyl with 1-10 C atoms, where two adjacent carbon atoms may form a double bond and/or one or two non-adjacent CH and/or CH₂ groups may be replaced with N, O and /or S and where 1-7 H atoms may be replaced with R⁵, or cyclic alkyl having 3-7 C atoms; A' denotes unbranched or branched alkyl with 1-6 C atoms, where one or two non-adjacent CH and/or CH 2 groups may be replaced with O atoms; Cyc denotes cyclobutyl, cyclopentyl, or cyclohexyl, each of which is unsubstituted or substituted once or twice with A, Hal, OR⁴, N(R⁴)₂, Het', (CR⁴)ₙO(CR⁴)ₙHet', CON (R⁴)₂ and/or =O; R⁵ denotes F, Cl or OH; Het denotes pyrrolidinyl, morpholinyl, piperidinyl, piperazinyl, [1,4]-diazepanil, oxazolidinyl, hexahydro-pyrrolo[3,4-c]pyrrolyl, 2-oxa-6-aza-spiro[3.4]octanyl, 2-oxa- 6-aza-spiro[3.5]nonanil, 2-oxa-7-aza-spiro[3.5]nonanil, 2,5-dioxa-8-aza-spiro[3.5]nonanil, oxetanil, 2-oxa-5-aza- spiro[3.4]octanyl, 2-oxa-6-aza-spiro[3.3]heptanyl, 3-aza-bicyclo[3.1.0]hexanyl, 2-oxa-7-aza-spiro[3.5]nonanyl, isoxazolidinyl, azetidinyl, 2,6-diaza-spiro[3.4]octanyl, hexahydro-pyrrolo[3,4-b]pyrrolyl, tetrahydrofuranyl, or isothiazolidinyl, each of which is unsubstituted or substituted once, twice, or three times with A, Hal, OR⁴, OCOA, COA, (CR⁴)ₙN(R⁴)₂, (CR⁴)ₙHet’, (CR⁴)ₙO(CR⁴)ₙHet’, CON(R⁴)₂, COHet’, (CR⁴)ₙS(O)ₘR⁴, and /o =O; Het' denotes pyrrolidinyl, morpholinyl, piperidinyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyridyl, pyrazolyl or piperazinyl, each of which is unsubstituted or substituted once or twice with A, Hal, OR⁴, N(R⁴)₂ and/or or =O; Hal denotes F, Cl, Br or I; n denotes 0, 1, 2 or 3; m denotes 0, 1 or 2; provided that only one or two of X¹, X², X³, X⁴ denote N; and their pharmaceutically acceptable salts, tautomers and stereoisomers, characterized in that they include mixtures thereof in all ratios. |