http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-106649-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2597173817e09714b1179ec87aeacbdc |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-24 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-114 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-195 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-56911 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-195 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-114 |
| filingDate | 2016-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b94085c1e2f1f4cceeae11da426d7292 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d371fbe03d1422826889bae17b6219b5 |
| publicationDate | 2018-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-106649-A1 |
| titleOfInvention | FUSOBACTERIUM POLIPEPTIDES AND THEIR METHODS OF USE |
| abstract | Isolated polypeptides that can be isolated from Fusobacterium spp. Also provided are compositions that include one or more of the polypeptides, as well as methods for making and using said polypeptides. Claim 5: A composition, characterized in that it comprises: isolated polypeptides having molecular weights of between 92 kDa and 79 kDa, between 73 kDa and 63 kDa, between 62 kDa and 58 kDa and between 57 kDa and 47 kDa, wherein the polypeptides are they can be isolated from a Fusobacterium necrophorum when incubated in a medium comprising an iron chelator and cannot be isolated when grown in the medium without the iron chelator, isolated polypeptides having molecular weights between 108 kDa and 98 kDa and between 79 kDa and 69 kDa, wherein the polypeptides are expressed by the Fusobacterium necrophorum when incubated in a medium without the iron chelator and are expressed at an improved level during growth in a medium comprising an iron chelator, and an isolated polypeptide that has at least 85% similarity to SEQ ID No. 2, a polypeptide that has at least 85% similarity to SEQ ID No. 4, a polypeptide that has at least 85% yes similarity to SEQ ID No. 6, a polypeptide that has at least 85% similarity to SEQ ID No. 34 or a combination thereof, wherein the composition protects mice against a challenge with Fusobacterium necrophorum. Claim 6: A composition, characterized in that it comprises: isolated polypeptides having molecular weights between 131 kDa and 121 kDa, between 79 kDa and 69 kDa and between 33 kDa and 23 kDa, wherein the polypeptides can be isolated from a Fusobacterium Necrophorum when incubated in a medium comprising a copper chelator and cannot be isolated when grown in the medium without the copper chelator and isolated polypeptides having molecular weights between 93 kDa and 83 kDa, between 65 kDa and 55 kDa and between 52 kDa and 42 kDa, wherein the polypeptides are expressed by the Fusobacterium necrophorum when incubated in a medium without the copper chelator and are expressed at an improved level during growth in a medium comprising a copper chelator, in where the composition protects mice against a challenge with Fusobacterium necrophorum. Claim 7: A composition, characterized in that it comprises: isolated polypeptides having molecular weights between 131 kDa and 121 kDa, between 108 kDa and 98 kDa, between 92 kDa and 64 kDa, between 53 kDa and 43 kDa, between 33 kDa and 19 kDa, wherein the polypeptides can be isolated from a Fusobacterium necrophorum when incubated in a medium comprising a zinc chelator and cannot be isolated when grown in the medium without the zinc chelator and isolated polypeptides having molecular weights between 79 kDa and 69 kDa and between 65 kDa and 55 kDa, where the polypeptides are expressed by Fusobacterium necrophorum when incubated in a medium without the zinc chelator and are expressed at an improved level during growth in a medium that It comprises a zinc chelator, wherein the composition protects mice against a challenge with Fusobacterium necrophorum. Claim 12: A method of treating an infection in a subject, characterized in that the method comprises: administering an effective amount of the composition of claim 1, 5, 6 or 7 to a subject who is at or at risk of having an infection caused by a Fusobacterium spp. |
| priorityDate | 2015-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 24.