http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-106516-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5a15c26ed920bde7a57742b39467c5a4 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2603-12 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C49-643 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C49-513 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-67 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C62-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C49-733 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-292 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-004 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-29 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J61-00 |
| filingDate | 2016-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f51eddd5026b34ada1feb2c60ad9dc2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c031c58e09f1b89a25e36b1a9de3c8ae |
| publicationDate | 2018-01-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-106516-A1 |
| titleOfInvention | PROCESS FOR THE PREPARATION OF 17b-HIDROXI-DES-A-ANDROST-9,10-EN-5-ONA |
| abstract | Process for the synthesis of 17b-hydroxy-des-A-androst-9,10-en-5-one, the compound of formula (1), which can be used as an intermediate in the synthesis of retroprogesterone. Claim 1: Process for the synthesis of 17b-hydroxy-des-A-androst-9,10-en-5-one, compound of formula (1), comprising the following steps: a) reaction of the compound (4eR, 6eS , 9eS, 9bS) -decaidro-6a-methyl-cyclopenta [f] [1] benzopyran-3,7-dione, compound of formula (2), with bromide or ethylmagnesium chloride to give the mixture of isomers (4S, 5R , 7aS) -5-hydroxy-7a-methyl-4- (3-isopentyl) octahydro-1H-inden-1-one and (4S, 5S, 7aS) -5-hydroxy-7a-methyl-4- (3- isopentyl) octahydro-1H-inden-1-one, intermediate mixture of formula (3); b) oxidation of the intermediate mixture of formula (3) to give (4S, 7aS) -7a-methyl-4- (3-isopentyl) hexahydro-1H-inden-1,5 (4H) -dione, intermediate of formula ( 4); c) cyclization of the intermediate of formula (4) to give des-A-androst-9,10-en-5,17-dione, intermediate of formula (5); d) reduction of the intermediate of formula (5) to 17b-hydroxy-des-A-androst-9,10-en-5-one, compound of formula (1). Claim 10: Mixture of formula (3) of the isomers of (4S, 5R, 7aS) -5-hydroxy-7a-methyl-4- (3-isopentyl) octahydro-1H-inden-1-one of formula (6) and (4S, 5S, 7aS) -5-hydroxy-7a-methyl-4- (3-isopentyl) octahydro-1H-inden-1-one of formula (7). |
| priorityDate | 2015-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.