http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-105975-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0ca0841c52dc980c3f201762d410f79b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-403 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5383 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4523 |
| filingDate | 2016-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be8caeadc746e395e87c0e45d45f0fd0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ee8020d8b55097aff664277d8876cd31 |
| publicationDate | 2017-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-105975-A1 |
| titleOfInvention | HETEROCYCLIC LIMITED TRICYLIC SULFONAMIDS AS AGENTS AGAINST CANCER |
| abstract | A genus of arylsulfonamide derivatives of heterocyclic limited tricyclic compounds is described. The compounds induce translocation of the FOXO1 transcription factor to the nucleus by modulating PP2A and, as a consequence, have antiproliferative effects. They are useful in the treatment of various disorders, including as a therapy in cancer treatment, or are used in combination with other drugs to restore sensitivity to chemotherapy where resistance has developed. Claim 1: A compound of formula (1), wherein D is selected from a direct bond, -O-, -CH₂O, -OCH₂ -, - C (= O) NRD- and -N (RD) C (= O) -; RD is selected from hydrogen and C₁₋₆ alkyl; T is a benzene ring or a five or six membered heteroaromatic ring; U is a benzene ring or a five or six membered heteroaromatic ring; X¹, X², X³ and X⁴ are independently selected, in each instance, from hydrogen, halogen, nitro, cyano, C alquilo alkyl, C₁₋₆ haloalkyl, C₁₋₆ haloalkoxy, C₁₋₆ haloalkylthio, -NR¹R², -OR¹, -C (O) R¹, -OC (O) R¹, -C (O) NR¹R², -C (O) OR¹, -SR¹, -SO₂R¹ and -SO₂NR¹R²; R¹ and R² are independently selected, in each instance, from the group consisting of hydrogen and C₁₋₆ alkyl; Q is selected from -O-, S (O) ₙ- and -NR-; n is zero, 1 or 2; R is selected from hydrogen, C₁₋₆ alkyl, C₃₋₇ cycloalkyl, aryl or optionally substituted heteroaryl; -SO₂R³; -SO₂N (R³R⁴); -C (= O) R⁵; -C (= O) OR⁵; or -C (= O) N (R³R⁴); wherein said substituents on the C₁₋₆ alkyl, C₃₋₇ cycloalkyl, aryl or heteroaryl are selected from the group consisting of hydroxy, halogen, cyano, nitro, amino, C₁₋₄ alkylamino, C₁₋₄ dialkylamino, C₁₋₄ acylamino , C₁₋₄ alkylsulfonyl, C₁₋₄ alkylthio, C₁₋₄ alkyl, C₃₋₇ cycloalkyl, C₁₋₄ haloalkyl, C₁₋₄ haloalkoxy and C₁₋₄ alkoxy; R³ and R⁴ are independently selected, in each instance, from hydrogen, C₁₋₆ alkyl, aryl and arylalkyl, wherein said aryl or aryl alkyl aryl is optionally substituted with hydroxy, halogen, cyano, nitro, amino, C₁₋₄ alkylamino , C₁₋₄ dialkylamino, C₁₋₄ acylamino, C₁₋₄ alkylsulfonyl, C₁₋₄ alkylthio, C₁₋₄ alkyl, C₁₋₄ haloalkyl, C₁₋₄ haloalkoxy or C₁₋₄ alkoxy; R⁵ is selected from hydrogen, optionally substituted C₁₋₄ alkyl or optionally substituted aryl, wherein said optional substituents are selected from the group consisting of C₁₋₃ alkyl, OR¹, NH₂, NHMe, N (Me) ₂ and heterocycle; And it is selected from hydrogen or hydroxyl; V is selected from phenyl, a six-membered heteroaromatic ring, furan and thiophene; Z¹ and Z² are independently selected, in each instance, from the group consisting of hydrogen, halogen, nitro, cyano, azide, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₁₋₆ haloalkoxy, haloalkylthio-C₁₋₆, -NR¹R², -NR¹C (O) R², -NR¹C (O) OR⁶, -OR¹, -C (O) R¹, -OC (O) R¹, -C (O) NR¹R², -C (O) OR¹, -SR¹, -SO₂R¹ and -SO₂NR¹R²; and R⁶ is C₁₋₈ hydrocarbon. |
| priorityDate | 2015-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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