http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-105911-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4a7ac31dafa9b644bcbf73f79c4695dc |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D265-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D279-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D279-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D265-36 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-538 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D279-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-06 |
| filingDate | 2016-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e703ea632dc84b7c5e59143c2edd831b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_444229e6805415f172df1926878e5ca6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d758272fa0085de58abd738e82f0cd01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f77f414f78bf44ce188a0965c0a406ca http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_03fe9b250eb9f6d6164602e6b2bdd13a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87bdbfdcd3b61bedbe7f9f23049b0819 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a03460c57fa9023aa3630766ee446031 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_997b0e98fc942e991cc674429918a4f3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f78019d1637a454b11eb23a0d55599f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d9dde16da2f1af7fa0ce89240e2ec83f |
| publicationDate | 2017-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-105911-A1 |
| titleOfInvention | FUSIONED BICYCLIC HDAC8 INHIBITORS [6,6] |
| abstract | Claim 1: A compound of formula (1), and its pharmaceutically acceptable salts, prodrugs, solvates, hydrates, isomers or tautomers, wherein: Y¹, Y², Y³ and Y⁴ are each independently N, C or CR³, provided that, when attached to -C(O)NHOH, any of Y¹, Y², Y³ or Y⁴ is C; X is selected from the group consisting of S(O)₂, S(O), S, O, C(=O), and C(R⁴)(R⁵); W is C(R⁴)(R⁵) or O; R¹ is independently C₁₋₆ alkyl, C₁₋₆ alkoxy, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₈ cycloalkyl, C₄₋₈ cycloalkenyl, aryl, heteroaryl, 3- to 8-membered heterocycle, -( CH₂)ₙ-Rᵃ, -(CH₂)ₙ-O-(CH₂)ₚ-Rᵃ, -S(O)₂Rᵃ, -C(O)Rᵃ, or -C(O)N(Rᵃ)(Rᵇ), in wherein each alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl or heterocycle is optionally substituted with one or more -OH, halogen, oxo, -NO₂, -NH₂, -CN, -C₁₋₆ alkyl, -C₁₋ alkoxy ₆, heterocycle, aryl, heteroaryl, or R⁴; Rᵃ is, at each occurrence, hydrogen, halogen, OH, NH₂, C₁₋₆ alkyl, C₁₋₆ alkoxy, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₈ cycloalkyl, C₄₋₈ cycloalkenyl, aryl, heteroaryl, heterocycle 3 to 8 membered, or -C(O)N(R¹⁰)(R¹¹), wherein each alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl, or heterocycle is optionally substituted with one or more -OH, R⁴ , R⁵, halogen, oxo, (CH₂)ₙOR⁶, -NO₂, -OR⁶, -N(R⁶)(R⁷), C(O)OR⁶, -C(O)N(R⁶)(R⁷), -S (O)₂R⁶, -S(O)R⁶, -S(R⁶), -C(O)R⁶, S(O)₂N(R⁶)(R⁷), -CN, -C₁₋₆-alkyl, -C₁₋-haloalkyl ₆, -C₁₋₆-alkoxy, C₁₋₆-alkylamino, C₁₋₆-dialkylamino, C₁₋₆-hydroxyalkyl, C₃₋₈-cycloalkyl, C₃₋₈-cycloalkylalkyl, arylalkyl, heterocycle, aryl, or heteroaryl; Rᵇ is, at each occurrence, hydrogen, halogen, OH, NH₂, C₁₋₆ alkyl, C₁₋₆ alkoxy, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₈ cycloalkyl, C₄₋₈ cycloalkenyl, aryl, heteroaryl, heterocycle 3 to 8 membered, or -C(O)N(R¹⁰)(R¹¹), wherein each alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl, or heterocycle is optionally substituted with one or more -OH, R⁴ , R⁵, halogen, oxo, (CH₂)ₙOR⁶, -NO₂, -OR⁶, -N(R⁶)(R⁷), C(O)OR⁶, -C(O)N(R⁶)(R⁷), -S (O)₂R⁶, -S(O)R⁶, -S(R⁶), -C(O)R⁶, -S(O)₂N(R⁶)(R⁷), -CN, -C₁₋₆-alkyl, -C₁-haloalkyl ₋₆, -C₁₋₆-alkoxy, C₁₋₆-alkylamino, C₁₋₆-dialkylamino, C₁₋₆-hydroxyalkyl, C₃₋₈-cycloalkyl, C₃₋₈-cycloalkylalkyl, arylalkyl, heterocycle, aryl, or heteroaryl; or Rᵃ and Rᵇ may combine with the carbon or nitrogen to which they are attached to form a 3- to 8-membered C₃₋₈ cycloalkyl or heterocycle optionally substituted with one or more substituents selected from R⁴ and R⁵, where R⁴ and R⁵ independently at each occurrence are H or -C₁₋₆ alkyl; R² and R² are independently hydrogen, C₁₋₆ alkyl, C₁₋₆ alkoxy, -OH, halogen, -NO₂, -NH₂, -CN, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₈ cycloalkyl , C₄₋₈ cycloalkenyl, aryl, heteroaryl, 3- to 8-membered heterocycle, wherein each alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl, or heterocycle is optionally substituted with one or more -OH, halogen, oxo, - NO₂, -NH₂, -CN, -C₁₋₆ alkyl, -C₁₋₆ alkoxy; or R² and R² can combine with the carbon to which they are attached to form a 3 to 8 membered oxo, C₃₋₈ cycloalkyl or heterocycle group; R³ is independently, at each occurrence, hydrogen, halogen, OH, CN, NO₂, NH₂, C₁₋₃ alkyl, or C₁₋₃ alkoxy; each R⁴ or R⁵ is each, independently, at each occurrence, hydrogen, halogen, OH, NH₂, C₁₋₆ alkyl, C₁₋₆ alkoxy, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₈ cycloalkyl, cycloalkenyl C₄₋₈, aryl, heteroaryl, 3- to 8-membered heterocycle, or -C(O)N(R¹⁰)(R¹¹), wherein each alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl, or heterocycle is optionally substituted with one or more -OH, R⁴, R⁵, halogen, oxo, -(CH₂)ₙOR⁶, -NO₂, -OR⁶, -N(R⁶)(R⁷), C(O)OR⁶, -C(O)N( R⁶)(R⁷), -S(O)₂R⁶, -S(O)R⁶, -S(R⁶), -C(O)R⁶, -S(O)₂N(R⁶)(R⁷), -CN, - C₁₋₆-alkyl, -C₁₋₆-haloalkyl, -C₁₋₆-alkoxy, C₁₋₆-alkylamino, C₁₋₆-dialkylamino, C₁₋₆-hydroxy-alkyl, C₃₋₈-cycloalkyl, C₃₋₈-cycloalkyl-alkyl, arylalkyl, heterocycle, aryl, or heteroaryl; or R⁴ and R⁵ may combine with the carbon or nitrogen to which they are attached to form a 3- to 8-membered oxo, C₃₋₈ cycloalkyl or heterocycle group, optionally substituted with one or more substituents selected from R⁴ and R⁵, in where R⁴ and R⁵, independently, at each occurrence, are H or -C₁₋₆ alkyl; or R⁴ and R⁵ together when attached to the same atom form a C₃₋₈ spirocycloalkyl ring; or R⁴ and R⁵ together when attached to the same atom form a C₃₋₈ spiroheterocycloalkyl ring; or R⁴ and R⁵ together when bonded to adjacent atoms form an aryl ring, a heteroaryl ring, a C₃₋₈ cycloalkyl ring, or a 3- to 8-membered heterocycle, wherein spirocycloalkyl, spiroheterocycloalkyl, heteroaryl, cycloalkyl, or heterocycle are optionally substituted with one or more groups selected from OH, halogen, -C₁₋₆ alkyl or C(O)OR⁶; R⁶ and R⁷ are each independently selected from the group consisting of hydrogen, C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₁₋₆ alkoxy, amino, C₁₋₆ alkylamino, C₁₋₆ dialkylamino , C₃₋₈ cycloalkyl, C₃₋₈ cycloalkenyl, aryl, heteroaryl, heterocycle, -S(O)₂NR⁸R⁹, -S(O)₂R⁸, -C(O)R⁸, -CO₂R⁸, -S(O)R⁸, or -S (O)NR⁸R⁹, wherein each alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, phenyl, heteroaryl or heterocycle is optionally substituted with one or more -OH, halogen, oxo, -NO₂, -NH₂, -CN, -C₁₋ alkyl ₆, -C₁₋₆-alkoxy, C₁₋₆-alkylamino, C₁₋₆-dialkylamino, hydroxy-C₁₋₆-alkyl, heterocycle, aryl, heteroaryl; or R⁶ and R⁷ together with an atom to which they are attached form a C₃₋₈ cycloalkyl or a 3- to 8-membered heterocycle, wherein the cycloalkyl or heterocycle is optionally substituted with one or more groups selected from halogen, oxo and C₁ alkyl ₋₆; R⁸ and R⁹ are each independently C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₈ cycloalkyl, C₃₋₈ cycloalkenyl, heteroaryl, or 3- to 8-membered heterocycle, wherein each is optionally substituted with one or more -OH, halogen, oxo, -NO₂, -NH₂, -CN, -C₁₋₆ alkyl, -C₁₋₆ alkoxy, C₁₋₆ alkylamino, C₁₋₆ dialkylamino, C₁ hydroxy ₋₆-alkyl, heterocycle, aryl, or heteroaryl; R¹⁰ and R¹¹ are each, independently, hydrogen, C₁₋₆ alkyl, aryl, C₁₋₆ alkylaryl, or 3- to 8-membered heterocycle; wherein aryl, arylalkyl, and heterocycle are optionally substituted with one or more groups selected from halogen, C₁₋₆ alkyl, and C₁₋₆ alkoxy; or R¹⁰ and R¹¹ may combine to form a 3 to 8 membered heterocycle optionally substituted with one or more R¹²; R¹² is H or C₁₋₆ alkyl or two adjacent R¹² may combine to form an aryl or heteroaryl group; n is an integer from 1 to 6; and p is an integer from 0 to 2; provided that the compound is not N-hydroxy-1-((4-methoxyphenyl)sulfonyl)-1,2,3,4-tetrahydroquinoline-6-carboxamide. |
| priorityDate | 2015-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 75.