http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-105839-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4fda45c540f11df3a7fe71d54a70562a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4035 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-407 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4035 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-407 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 |
| filingDate | 2016-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-105839-A1 |
| titleOfInvention | ANTIBACTERIAL DERIVATIVES PIRROLIDIN-2-ONA ANNULARS |
| abstract | Claim 1: A compound of formula (1) wherein X represents sulfur or CH = CH; R¹ represents H, PO₃H₂, SO₃H, phosphonooxymethyl or the group of formula (2), where R² represents C₁₋₄ alkylaminoC₁₋₄ alkyl, Cquil-dialkyl alkyl-C₁₋₄ alkyl, phosphonooxy-C₁₋₄ alkyl, phosphonooxymethoxy, 2- (phosphonooxy-C₁₋₄ alkyl) -phenyl, [2- (phosphonooxy-C₁₋₄ alkyl) -phenyl] -C₁₋₄ alkyl, or (2- (phosphonooxy) -phenyl) -C₁₋₄ alkyl; M is one of the groups of formula (3) and (4), where A represents a bond or C; R¹A represents H or halogen; R²A represents H or halogen; R³A represents H, C₁₋₃ alkoxy, C₂₋₄ hydroxy-alkoxy, C₁₋₄ hydroxy-alkyl, 1,2-dihydroxyethyl, (3-fluoroazetidin-1-yl) methyl, 3-fluoro-1- (oxetan-3 -yl) azetidin-3-yl, 3-fluoro-1-methyl-azetidin-3-yl, (4-hydroxy-3-fluoropiperidin-1-yl) methyl, (4-hydroxy-3,3-difluoropiperidin-1 -yl) methyl, (3-hydroxyazetidin-1-yl) methyl, 3- (w-hydroxy-C₂₋₄ alkyl) -azetidin-1-yl, 1- (oxetan-3-yl) azetidin-3-yl, 1- (oxetan-3-ylmethyl) azetidin-3-yl or (4-hydroxypiperidin-1-yl) methyl; and R¹B represents amino C₁₋₃ alkyl, 1-amino-cycloprop-1-yl, trans-2- (2-dimethylaminoacetoxymethyl) -cycloprop-1-yl, 1- (2-dimethylaminoacetoxymethyl) -cycloprop-1-yl, 1- (3-hydroxyazetidine) -1-carbonyloxymethyl, 1-hydroxymethyl-cycloprop-1-yl, trans-2-hydroxymethyl-cycloprop-1-yl, 1-fluoro-2-hydroxymethyl-cycloprop-1-yl, 2- fluoro-2-hydroxymethyl-cycloprop-1-yl, 1 - {[(2- (phosphonooxy-C₁₋₄-alkyl) -phenyl) -C-alkyl] carbonyloxymethyl} cycloprop-1-yl, 1 - {[2- (phosphonooxy-C₁₋₄ alkyl) -phenyl] carbonyloxymethyl} cycloprop-1-yl, 1 - {[(2-phosphonooxy-phenyl) -C1 alkyl] carbonyloxymethyl} cycloprop-1-yl, trans-2- { [(2- (phosphonooxy-C₁₋₄ alkyl) -phenyl) -C₁₋₄ alkyl] carbonyloxymethyl} cycloprop-1-yl, trans-2 - {[2- (phosphonooxy-C₁₋₄ alkyl) -phenyl] carbonyloxymethyl} cycloprop-1-yl, trans-2 - {[(2-phosphonooxy-phenyl) -C₁₋₄ alkyl] carbonyloxymethyl} cycloprop-1-yl, 2-fluoro-2 - {[(2- (phosphonooxy-C₁₋ alkyl) ₄) -phenyl) -C₁₋₄ alkyl] carbonyloxymethyl} cycloprop-1-yl, 2-fluor o-2 - {[2- (phosphonooxy-C₁₋₄ alkyl) -phenyl] carbonyloxymethyl} cycloprop-1-yl, 2-fluoro-2 - {[(2-phosphonooxy-phenyl) -C₁₋₄ alkyl] carbonyloxymethyl} cycloprop-1-yl, 2-fluoro-2- (phosphonooxymethyl) -cycloprop-1-yl, 1-methyl-2-hydroxymethyl-cycloprop-1-yl, 2-hydroxymethyl-2-methylcycloprop-1-yl, 1- (2-hydroxyacetyl) -azetidin-3-yl, trans- (cis-3,4-dihydroxy) -cyclopent-1-yl, 2- (1,2-dihydroxyethyl) cycloprop-1-yl, 1- (dimethylamino) cycloprop-1-yl, 2- (morpholinomethyl) cycloprop-1-yl, 2 - ((3-fluoroazetidin-1-yl) methyl) cyclopropyl, N-alkyl C₁₋₄-azetidin-3-yl, N-cycloalkyl C₃ ₋₆-azetidin-3-yl, 3-fluoro-1-methyl-azetidin-3-yl, 1- (methylamino) cycloprop-1-yl, N- (w-hydroxy-C₂₋₄ alkyl) -azetidin-3 -yl, 2- (hydroxymethyl) -1-methylazetidin-3-yl, N- (2-hydroxy-2-methylpropyl) azetidin-3-yl, N- (w-haloalkyl C₂₋₄) -azetidin-3-yl , 1- (3-hydroxypropyloxycarbonyl) -azetidin-3-yl, 2- (fluoromethyl) -1-methylazetidin-3-yl, N- (3-hydroxycyclobutyl) azetidin-3-yl, N- (oxetan-3-ylmethyl ) azetidin-3-yl, N- ( 3-hydroxyoxetan-3-ylmethyl) azetidin-3-yl, N- (tetrahydrofuran-3-yl) azetidin-3-yl, N- (tetrahydro-2H-piran-4-yl) azetidin-3-yl, trans- 2-hydroxymethyl-1-methylazetidin-4-yl, (5-hydroxymethyl) -1-methylpyrrolidin-3-yl, 4-fluoro-1-methylpiperidin-4-yl, or 1- (oxetan-3-yl) -azetidin -3-yl; or a salt thereof. |
| priorityDate | 2015-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 25.