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filingDate 2016-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2017-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber AR-105822-A1
titleOfInvention INSULIN ANALOGS
abstract Claim 1: An insulin analog peptide comprising an A chain of SEQ ID No. 3 indicated in the general formula (1) and a B chain of SEQ ID No. 4 indicated in the general formula (2), (general formula 1): Gly-Ile-Val-Glu-Gln-Cys-Cys-Thr-Ser-Ile-Cys-Ser-Leu-Xaa-G1n-Leu-Glu-Asn-Tyr-Cys-Asn (SEQ ID No. 3) where Xaa it is glutamic acid or asparagine; and (general formula 2): Phe-Val-Asn-Gln-His-Leu-Cys-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cys-Gly-Glu-Arg -Gly-Phe-Xaa-Tyr-Thr-Pro-Lys-Thr (SEQ ID No. 4) where Xaa is phenylalanine or is suppressed. Claim 8: A nucleic acid encoding the insulin analog peptide according to any one of claims 1 to 7. Claim 11: A transformant that is transformed with the recombinant expression vector according to claim 10. Claim 13: A a method for preparing the insulin analog peptide according to claim 1, comprising: a) the preparation of a recombinant expression vector comprising a nucleic acid encoding the insulin analog peptide according to claim 1; b) the transformation of the recombinant expression vector into a host cell and obtaining a transformant thereof; c) culture of the transformant and expression of the insulin analog peptide; and d) isolation and purification of the expressed insulin analog peptide. Claim 17: A pharmaceutical composition for the treatment of diabetes comprising the insulin analog peptide according to any one of claims 1 to 7 and a pharmaceutically acceptable carrier.
priorityDate 2015-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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