http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-105494-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1f67dd95fb433cb3458c52756dbd5b4c |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D235-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4184 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4184 |
| filingDate | 2016-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_763a141e1f05e162e9b9e48862a42727 |
| publicationDate | 2017-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-105494-A1 |
| titleOfInvention | METHOD FOR PREPARING ACID DERIVATIVES 3- (2-ANILINO-1-CICLOHEXIL-1H-BENCIMIDAZOL-5-IL) SUBSTITUTED PROPANOIC |
| abstract | Claim 1: Method for preparing a compound of the general formula (1), wherein R¹ represents a hydrogen atom or R¹ represents a group selected from the C₁₋₃-alkyl-, C₁₋₃-alkoxy- series, C₁₋₃-haloalkyl- and C₁₋₃-haloalkoxy-; R² represents a hydrogen atom or a C₁₋₃-alkyl group; R³ represents a hydrogen atom or a C₁₋₃-alkyl group; R⁴ represents a cyclohexyl group, which is substituted simply or multiplely by a C₁₋₃-alkyl group; and R⁵ represents a hydrogen atom or a C₁₋₆-alkyl group; wherein the method comprises a step in which a compound of the general formula (2), in which R⁴ has the same definition as for the compound of formula (1) and R⁶ represents a C₁₋₆-alkyl group, or a salt or a solvate or a solvate of a salt of the compound of the general formula (2); it is reacted with a compound of the general formula (3), in which R¹, R² and R³ have the same meaning as for the compound of the formula (1); and in this reaction a compound of the general formula (4) is formed, in which R¹, R², R³ and R⁴ have the same meaning as for the compound of the formula (1) and R⁶ has the same definition as for the compound of the formula (2). Claim 7: Method according to claim 1 for preparing 3- (2 - {[4- (trifluoromethoxy) phenyl] amino} -1 - [(1R, 5R) -3,3,5-trimethylcyclohexyl] -1H- benzimidazol-5-yl) propanoic acid, wherein the method comprises a step in which an alkyl ester of 3- (3-amino-4 - {[(1R, 5R) -3,3,5-trimethylcyclohexyl] amino acid } phenyl) propanoic acid of the formula (5), in which R⁶ represents a C₁₋₆-alkyl group; or a salt or a solvate or a solvate of a salt of the compound of the formula (5), is reacted with 4-isothiocyanophenyltrifluoromethyl ether, of formula (6), and in this reaction the alkyl ester of acid 3- is formed (2 - {[4- (trifluoromethoxy) phenyl] amino} -1 - [(1R, 5R) -3,3,5-trimethylcyclohexyl] -1H-benzimidazol-5-yl) propanoic acid of the formula (7), in which R⁶ has the same definition as for the compound of the formula (5). |
| priorityDate | 2015-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 27.