http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-105246-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_daa292fcadd45459a7454f2ed8053305 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4409 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-397 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-145 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C321-16 |
| filingDate | 2016-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a32c1a89de38942f905339173bd20fed http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_292d2d7d16308ccfd52a02293b2b2e31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8264ca41dd377d5409a705c1bd4370e5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1004eb281b8b18c974682a80bb84d6fb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_658d6bc915ad46d36c814c63652feeae |
| publicationDate | 2017-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-105246-A1 |
| titleOfInvention | CISTEAMINE ANALOGS RESISTANT TO ADO AND ITS USES |
| abstract | Claim 1: A method of treating a patient suffering from a disease for which a cysteamine treatment is indicated, comprising administering to the patient an effective amount of a composition comprising a compound of formula (1) or a disulfide thereof, where: R¹ and R² are independently selected from the group consisting of H and C₁₋₅alkyl; or R¹ and R², taken together with the carbon atom to which they are attached, form a carbocyclic ring of 3, 4, 5, 6, 7 or 8 members; R³ and R⁴ are independently selected from the group consisting of H and C₁₋₅alkyl; or R³ and R⁴, taken together with the carbon atom to which they are attached, form a carbocyclic ring of 3, 4, 5, 6, 7 or 8 members; G is selected from the group consisting of -NR⁵R⁶ and -CR⁷R⁸NR⁵R⁶; R⁵ and R⁶ are independently selected from the group consisting of H and C₁₋₅alkyl; or R⁵ and R⁶, taken together with the nitrogen atom to which they are attached, form a 3, 4, 5, 6, 7 or 8-membered heterocyclic ring; R⁷ and R⁸ are independently selected from the group consisting of H and C₁₋₅alkyl; or R⁷ and R⁸, taken together with the carbon atom to which they are attached, form a carbocyclic ring of 3, 4, 5, 6, 7 or 8 members; R² and R⁶, taken together with the atoms to which they are attached, form a heterocyclic ring of 4, 5, 6, 7, 8, 9 or 10 members; R⁴ and R⁶, taken together with the atoms to which they are attached, form a heterocyclic ring of 4, 5, 6, 7, 8, 9 or 10 members; R² and R⁸, taken together with the atoms to which they are attached, form a carbocyclic ring of 3, 4, 5, 6, 7 or 8 members; or R² and R⁴, taken together with the atoms to which they are attached, form a carbocyclic ring of 3, 4, 5, 6, 7 or 8 members; with the proviso that when G is -NH₂, at least one of R¹, R², R³, and R⁴ is not H. Claim 40: A compound having the structure of formula (2) or a disulfide thereof, where R¹ is C₁₋₅alkyl; and R³, R⁴, R⁵, R⁷, and R⁸ are independently selected from the group consisting of H and C₁₋₅alkyl. Claim 41: A compound having the structure of formula (3) or a disulfide thereof, wherein R¹, R³, R⁴, R⁵, R⁶, and R⁷ are independently selected from the group consisting of H and C₁₋₅alkyl. |
| priorityDate | 2015-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 27.