http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-104985-A2
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_94274673988dbdb1ce6c89aa470393e6 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4184 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 |
filingDate | 2016-06-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2017-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | AR-104985-A2 |
titleOfInvention | BENCIMIDAZOL DERIVATIVES; PREPARATION AND PHARMACEUTICAL APPLICATIONS |
abstract | Claim 1: A compound, characterized in that it has the formula (1), wherein R¹ is selected from the group consisting of: H, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, heteroalkyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, heteroaryl , cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, heteroarylalkyl, arylalkenyl, cicloalquilheteroalquilo, arylheteroalkyl, heterocicloalquilheteroalquilo, heteroarylheteroalkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, alkoxyaryl, alkenyloxy, alkynyloxy, cycloalkyloxy, heterocycloalkyloxy, aryloxy, heteroaryloxy, arylalkyloxy, amino, alkylamino, aminoalkyl, acylamino , arylamino, phenoxy, benzyloxy, COOH, alkoxycarbonyl, alkylaminocarbonyl, sulfonyl, alkylsulfonyl, alkylsulfinyl, arylsulfonyl, arylsulfinyl, aminosulfonyl, SR⁴ and acyl, each of which may be unsubstituted or substituted with one or more substituents selected individually dependent on the group consisting of: halogen, = O, = S, -CN, -NO₂, -CF₃, -OCF₃, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, heteroalkyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, heteroaryl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, alkoxyaryl, alkoxyheteroaryl, alkenyloxy, alkynyloxy, cycloalkyloxy, cycloalkenyloxy, heterocycloalkyloxy, heterocycloalkenyloxy, aryloxy, heteroaryloxy, arylalkyl, heteroarylalkyl, arylalkyloxy, amino, alkylamino, acylamino, aminoalkyl, arylamino, sulfonyl, alkylsulfonyl , arylsulfonyl, arylsulfinyl, aminosulfonyl, aminoalkyl, alkoxyalkyl, -COOH, -C (O) OR⁵, -COR⁵, -SH, -SR⁶, -OR⁶ and acyl; or R¹ = L; R² is selected from the group consisting of: H, halogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, heteroalkyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, heteroylalkyl, heterocycloalkyl, heteroalkyl, heterocycloalkyl, heteroalkyl, heteroalkyl, heteroaryl, cycloalkyl, heteroylalkyl, heteroylalkyl, heteroaryl, alkyl heteroarylheteroalkyl, arylheteroalkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, alkoxyaryl, alkenyloxy, alkynyloxy, cycloalkyloxy, heterocycloalkyloxy, aryloxy, heteroaryloxy, arylalkyloxy, amino, alkylamino, aminoalkyl, acylamino, arylamino, phenoxy, benzyloxy, COOH, alkoxycarbonyl, alkylaminocarbonyl, sulfonyl, alkylsulfonyl, alkylsulfinyl, arylsulfonyl, arylsulfinyl, aminosulfonyl, SR⁵ and acyl, each of which may be unsubstituted or substituted with one or more substituents independently selected from the group consisting of: halogen, = O, = S, -CN, - NO₂, -CF₃, -OCF₃, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, heteroalkyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, heteroaryl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, alkoxyaryl, alkoxyheteroaryl, alkenyloxy, alkynyloxy, cycloalkyloxy, cycloalkenyloxy, heterocycloalkyloxy , heterocycloalkenyloxy, aryloxy, heteroaryloxy, arylalkyl, heteroarylalkyl, arylalkyloxy, -amino, alkylamino, acylamino, aminoalkyl, arylamino, sulfonyl, alkylsulfonyl, arylsulfonyl, aminosulfonyl, aminoalkyl, alkoxyalkyl -OR, -COOH, -CO⁵, -COOH, -CO⁵, -CO⁵, OR⁵, -COOH, OR⁵, -COOH, OR⁵, -COOH, -CO⁵, OROH, -COOH, -CO⁵, -CO⁵, -COOH, SH, -SR⁵, -OR⁶ and acyl; or R² = L; R³ is selected from the group consisting of H, C₁₋₆ alkyl and acyl; or a metal ion selected from sodium, calcium, magnesium; X and Y are the same or different and are independently selected from the group consisting of: H, halogen, -CN, -NO₂, -CF₃, -OCF₃, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, heteroalkyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, heteroaryl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, alkoxyaryl, alkoxyheteroaryl, alkenyloxy, alkynyloxy, cycloalkyloxy, cycloalkenyloxy, heterocycloalkyloxy, heterocycloalkenyloxy, aryloxy, heteroaryloxy, arylalkyl, heteroarylalkyl, arylalkyloxy, amino, alkylamino, acylamino , aminoalkyl, arylamino, sulfonyl, alkylsulfonyl, arylsulfonyl, aminosulfonyl, aminoalkyl, alkoxyalkyl, -COOH, -C (O) OR⁵, -COR⁵, -SH, -SR⁶, -OR⁶, acyl and -NR⁷R⁸; each R⁴ is selected from the group consisting of: H, alkyl, alkenyl, alkynyl, haloalkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, heteroarylalkyl and acyl; each R⁵ is independently selected from the group consisting of: alkyl, alkenyl, alkynyl, haloalkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, heteroarylalkyl and acyl; each R⁶ is independently selected from the group consisting of: alkyl, alkenyl, alkynyl, haloalkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, heteroarylalkyl and acyl; each R⁷ and R⁸ are each independently selected from the group consisting of: H, alkyl, alkenyl, alkynyl, haloalkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, heteroarylalkyl and acyl; L is selected from the group consisting of: a) L = Cy-L¹-W- wherein Cy is C₁₋₁₅ alkyl, aminoalkyl, heterocycloalkyl, cycloalkyl, aryl, aryloxy or heteroaryl, each of which may be optionally substituted with one or several substituents independently selected from the group consisting of: halogen, = O, = S, -CN, -NO₂, -CF₃, -OCF₃, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, heteroalkyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, heteroaryl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, alkoxyaryl, alkoxyheteroaryl, alkenyloxy, alkynyloxy, cycloalkyloxy, cycloalkenyloxy, heterocycloalkyloxy, heterocycloalkenyloxy, aryloxy, heteroaryloxy, arylalkyl, heteroarylalkyl, arylalkyloxy, amino, alkylamino, acylamino, aminoalkyl , arylamino, sulfonyl, alkylsulfonyl, arylsulfonyl, aminosulfonyl, -aminoalkyl, alkoxyalkyl, -COOH, -C (O) OR⁵, -COR⁵, -SH, -SR⁶, -OR⁶ and acyl; L¹ is selected from the group consisting of C₁₋₅ alkyl, which may be optionally substituted with one or more substituents independently selected from the group consisting of: halogen; = O; = S; -CN; -NO₂; alkyl, alkoxy, acylamino and alkylamino; W is selected from the group consisting of a single link, -O-, -S-, -S (O) -, -S (O) ₂-, -N (R⁹) -, -C (O) N (R⁹) -, -SO₂N (R⁹) -, N (R⁹) C (O) -, N (R⁹) SO₂- and -N (R⁹) -C (O) -N (R¹⁰) -; b) L = Cy-L¹-W-L² where, Cy is C₁₋₁₅ alkyl, aminoalkyl, heterocycloalkyl, cycloalkyl, aryl, -aryloxy or heteroaryl, each of which may be optionally substituted with one or more substituents selected from mode independent of the group consisting of: halogen, = O, = S, -CN, -NO₂, -CF₃, -OCF₃, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, heteroalkyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl , heteroaryl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, alkoxyaryl, alkoxyheteroaryl, alkenyloxy, alkynyloxy, cycloalkyloxy, cycloalkenyloxy, heterocycloalkyloxy, heterocycloalkenyloxy, aryloxy, heteroaryloxy, arylalkyl, heteroarylalkyl, arylalkyloxy, amino, alkylamino, acylamino, aminoalkyl, arylamino, sulfonyl, alkylsulfonyl, arylsulfonyl, aminosulfonyl, aminoalkyl, alkoxyalkyl, -COOH, C (O) OR⁵, -COR⁵, -SH, -SR⁵, -OR⁶ and acyl; L¹ and L² are the same or different and are, independently, C₁₋₅ alkyl, which may be optionally substituted with one or more substituents independently selected from the group consisting of: halogen; = O; = S; -CN; -NO₂; -CF₃, -OCF₃, alkyl, alkoxy, acylamino and alkylamino; W is selected from the group consisting of a single link, -O-, -S-, -S (O), -S (O) ₂-, -N (R⁹) -, -C (O) N (R⁹) - , -SO₂N (R⁹) -, N (R⁹) C (O) -, N (R⁹) SO₂- and -N (R⁹) -C (O) -N (R¹⁰) -; c) L = Cy- (CH₂) ₘ-W- wherein, Cy is C₁₋₁₅ alkyl, aminoalkyl, heterocycloalkyl, cycloalkyl, aryl, aryloxy or heteroaryl, each of which may be optionally substituted with one or more selected substituents independently of the group consisting of: halogen, = O, = S, -CN, -NO₂, -CF₃, -OCF₃, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, heteroalkyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, heteroaryl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, alkoxyaryl, alkoxyheteroaryl, alkenyloxy, alkynyloxy, cycloalkyloxy, cycloalkenyloxy, heterocycloalkyloxy, heterocycloalkenyloxy, aryloxy, heteroaryloxy, arylalkyl, arylamino, amino, alkylamino, amino, alkylamino, alkylamino, amino, alkylamino, alkylamino, alkylamino, alkylamino, amino , alkylsulfonyl, arylsulfonyl, aminosulfonyl, aminoalkyl, alkoxyalkyl, -COOH, C (O) OR⁵, -COR⁵, -SH, -SR⁵, -OR⁶ and acyl; m is 0, 1, 2, 3, 4 or 5; W is selected from the group consisting of a single link, -O-, -S-, -S (O) -, -S (O) ₂-, -N (R⁹) -, -C (O) N (R⁹) -, -S (O) ₂N (R⁹) -, N (R⁹) C (O) -, N (R⁹) SO₂- and -N (R⁹) -C (O) -N (R¹⁰) -; d) L = L¹-W-L² where L¹ and L² are the same or different and are independently selected from C₁₋₅ alkyl, which may be optionally substituted with one or more substituents independently selected from the group consisting of: halogen; = O; = S; -CN; -NO₂; -CF₃, -OCF₃, alkyl, alkoxy, acylamino, alkylamino; W is selected from the group consisting of a single link, -O-, -S-, -S (O) -, -S (O) ₂-, -N (R⁹) -, -C (O) N (R⁹) -, -SO₂N (R⁹) -, N (R⁹) C (O) -, N (R⁹) SO₂- and -N (R⁹) -C (O) -N (R¹⁰) -; R⁹ and R¹⁰ are the same or different and are independently selected from H, C₁₋₆ alkyl, C₄₋₉ cycloalkyl, C₄₋₉ heterocycloalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl; and acyl; Z is a single bond or is selected from -CH₂-, -CH₂CH₂-, -CH = CH-, C₃₋₆ cycloalkyl, unsubstituted or substituted with one or more substituents independently selected from the group consisting of C₁₋₄ alkyl; or one of its pharmaceutically acceptable salts. |
priorityDate | 2003-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 43.