| abstract |
The present application relates to pharmaceutically acceptable compounds and salts thereof useful for treating immunological disorders. Claim 1: A compound characterized in that it is of formula (1), a pharmaceutically acceptable salt, or a stereoisomer thereof, wherein W is C or CRᵃ, L¹ is connected to W or Y; and A and E are independently C or N with the proviso that they are not both N; V is CR³ or N; X is CRᵃ, NRᵃ, N, or O; Y is C, CRᵃ, NRᵃ, N, O or S; Z is CR³ or N; or W is N or NRᵃ, L¹ is connected to W or Y; and A and E are independently C or N with the proviso that they are not both N; V is CR³ or N; X is CRᵃ, NRᵃ, or N; Y is C, CRᵃ, or N; Z is CR³ or N; or Cy is a six-membered aromatic, heteroaromatic or partially saturated ring substituted with R¹ and R²; L¹ is -CH (Rᵇ) -, -C (Rᵇ) (Rᵈ) -, -C (O) - or -N (Rᶜ) -; L² is -C (O) -, -O-, -C (Rᵇ) (Rᵈ) -, -S-, -S (O) -, -S (O) ₂-; R¹ and R² are independently halo, -O-C₁₋₃ alkyl, -O-C₃₋₆ cycloalkyl, optionally substituted C₃₋₆ cycloalkyl, or -C₁₋₃ alkyl; each R³ is independently H, CF₃, CN, halo, -C (= O) C₁₋₃ alkyl, -C (O) N (Rᵉ) ₂, -NRᵉCORᵉ, -OCHF₂, OCF₃, -O-C₁₋₃ alkyl, -O-C₃₋₆ cycloalkyl, -S-C₁₋₃ alkyl, C₁₋₆ optionally substituted alkyl, C₃₋₆ optionally substituted cycloalkyl, optionally substituted heteroaryl or optionally substituted heterocycle; R⁴ is H, -OH, C₁₋₆ optionally substituted alkyl, -NR⁵R⁶, C₃₋₆ optionally substituted cycloalkyl or - (CH₂) ₘ-optionally substituted heterocycle; where R⁵ is H or -C₁₋₃ alkyl, and R⁶ is C₁₋₄ optionally substituted alkyl, C₃₋₆ cycloalkyl optionally substituted or - (CH₂) ₘ-heterocycle optionally substituted; or R⁵ and R⁶, together with the nitrogen atom to which they are attached, form an optionally substituted heterocycle; each Rᵃ is independently H, -C (O) CH₃, C₁₋₆ optionally substituted alkyl, C₃₋₆ optionally substituted cycloalkyl or -S (O) ₂-phenyl; each Rᵇ is independently H, F, OH, -O-C₁₋₃ alkyl, or C₁₋₃ alkyl; Rᶜ is independently H or -C₁₋₃ alkyl; each Rᵈ is independently H, F, or C₁₋₃ alkyl; or Rᵈ and Rᵇ form a C₃₋₅ spirocycle; Rᵉ is independently H or -C₁₋₃ alkyl; and m is independently 0 or 1; with the proviso that no more than two of A, E, W, X and Y are N. |