http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-102177-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eccd894c99fea2d1c0c8735872bb2309 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-553 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2015-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-102177-A1 |
| titleOfInvention | HETEROARILO COMPOUNDS AS BTK INHIBITORS AND USES OF THE SAME |
| abstract | Pyridine imidazo compounds, and pharmaceutically acceptable compositions thereof, useful as BTK inhibitors. Claim 1: A compound of formula (1), or a tautomer, or a pharmaceutically acceptable salt thereof, wherein: Ring A is a 5- to 6-membered aryl or heteroaryl; R¹ is H, halo, (C (R⁵) (R⁵)) ₘNR², N (R⁴) C (O) R, N (R⁴) C (O) NR₂, N (R⁴) CO₂R, N (R⁴) S (O ) ₂R, N (R⁴) S (O) R, N (R⁴) (R⁴), optionally substituted 3 to 7-membered heterocyclic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen or sulfur, or optionally monocyclic heteroaryl ring substituted from 5 to 6 members having 1-4 heteroatoms independently selected from nitrogen, oxygen or sulfur; or R¹ is absent; R² is H, (C (R⁵) (R⁵)) ₘOR⁴, (C (R⁵) (R⁵)) ₘN (R⁴) COR, (C (R⁵) (R⁵)) ₘN (R⁴) C (O) C (O ) NR₂, (C (R⁵) (R⁵)) ₘN (R⁴) (R⁴), optionally substituted 3 to 7-membered heterocyclic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen or sulfur, or optionally substituted monocyclic heteroaryl ring 5 to 6 members having 1-4 heteroatoms independently selected from nitrogen, oxygen or sulfur; or R² is absent; or R¹ and R² together with the atoms to which they are connected, form a condensed ring of 3 to 7 members which is optionally substituted; where R¹ and R² are none H; and where R¹ and R² are none absent; each R³ is independently halogen, aliphatic C₁₋₆, aryl C₅₋₁₀, a saturated or partially unsaturated carbocyclic ring of 3 to 8 members, a 3 to 7 member heterocyclic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen or sulfur, or a 5- to 6-membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen or sulfur; each of which is optionally substituted; each R⁴ is independently -R, -SO₂R, -SOR, -C (O) R, -CO₂R or -C (O) N (R) ₂; each R⁵ is independently -R, halogen, -OR, -SR, -CN, -NO₂, -SO₂R, -SOR, -C (O) R, -CO₂R, -C (O) N (R) ₂, -NRC (O) R, -NRC (O) N (R) ₂, -NRSO₂R or -N (R) ₂; each R is independently hydrogen, C₁₋₆ aliphatic, C₅₋₁₀ aryl, a 3 to 8 membered saturated or partially unsaturated carbocyclic ring, a 3 to 7 membered heterocyclic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen or sulfur, or a 5- to 6-membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen or sulfur; each of which is optionally substituted; or two R groups in the same atom are taken together with the atom to which they are attached to form a C₅₋₁₀ aryl, a saturated carboxylic ring or partially unsaturated 3 to 8 members, a 3 to 7 member heterocyclic ring having 1 - 4 heteroatoms independently selected from nitrogen, oxygen or sulfur, a 5- to 6-membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen or sulfur; a condensed aryl ring of 10 to 15 members; a saturated or partially unsaturated condensed carbocyclic ring of 6 to 15 members; a condensed heteroaryl ring of 10 to 15 members; or a saturated or partially unsaturated condensed heterocyclic ring of 6 to 15 members; each of which is optionally substituted; Ring Z is C₅₋₁₀ aryl, a saturated 3 or 8-membered carbocyclic ring, a 3- to 7-membered heterocyclic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen or sulfur, or a monocyclic heteroaryl ring 5 to 6 members having 1-4 heteroatoms independently selected from nitrogen, oxygen or sulfur; each of which is optionally substituted; or Ring Z is absent; each Rᵃ is independently -R, halogen, -OR, -SR, -CN, -NO₂, -SO₂R, -SOR, -C (O) R, -CO₂R, -C (O) N (R) ₂, -NRC (O) R, -NRC (O) N (R) ₂, -NRSO₂R or -N (R) ₂; m is 1, 2 or 3; n is 0, 1 or 2; and p is 0, 1, 2 or 3. |
| priorityDate | 2014-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 63.