http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-101950-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9e370f8d6396bfa6c1be69405003e7ae |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 |
| filingDate | 2015-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f2997b59a5faaf44b7355dadbb61d52e |
| publicationDate | 2017-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-101950-A1 |
| titleOfInvention | C-20 STEROID COMPOUNDS, THEIR COMPOSITIONS AND USES TO TREAT TRAUMATIC BRAIN INJURY (TBI), INCLUDING BRAIN CONMOTIONS |
| abstract | This refers to C-20 steroid compounds, their compositions and methods of use to treat, minimize and / or prevent traumatic brain injury (TBI), which include severe TBI, moderate TBI and mild TBI, which include concussions. Claim 1: A compound of formula (1), or a pharmaceutically acceptable salt, ester, prodrug or co-crystal thereof, wherein X is O, N or S; Y is O, N or S; or, YR⁸R¹⁰ is absent; R¹, R², R⁵, and R⁶ are independently H, C₁₋₆ alkyl, halogen, OR¹², NR¹³R¹⁴, SR¹⁵, SOR¹⁶ or SO₂R¹⁷; R⁴ is H or C₁₋₆ alkyl; R⁴ together with R³ and X forms an optionally substituted 5-6 membered heterocycle containing 1-2 atoms of nitrogen, oxygen or sulfur; or R⁴ and R⁷ together form a double bond; R³ is H or C₁₋₆ alkyl; R³ together with R⁴ and X forms an optionally substituted 5-6 membered heterocycle containing 1-2 nitrogen atoms, oxygen or sulfur, or R³ is absent; R⁷ is absent, H, C (O) -C₁₋₆ alkyl, C₁₋₆ alkyl; or R⁷ and R⁴ together form a double bond; R⁸ is H, C (O) -C₁₋₆ alkyl, C₁₋₆ alkyl; R⁸ together with R⁹ and Y forms an optionally substituted 5-6 membered heterocycle containing 1-2 nitrogen atoms, oxygen or sulfur, or R⁸ is absent; R⁹ is H or C₁₋₆ alkyl; R⁹ together with R⁸ and Y forms an optionally substituted 5-6 membered heterocycle containing 1-2 atoms of nitrogen, oxygen or sulfur; R⁹ and R¹¹ together form a double bond; R¹⁰ is absent, H, C (O) -C₁₋₆ alkyl, C₁₋₆ alkyl; or R¹⁰ and R¹¹ together form a double bond; R¹¹ is H or C₁₋₆ alkyl; or R¹¹ and R¹⁰ together form a double bond; R¹¹ and R⁹ together form a double bond; R¹², R¹³, R¹⁴, R¹⁵, R¹⁶ and R¹⁷ are independently H, C (O) -C₁₋₆ alkyl, C₁₋₆ alkyl; and the broken line indicates the presence of a single or double bond where the valences of a single bond are completed with hydrogens. |
| priorityDate | 2014-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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