http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-101498-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_12a2b2c13638e198ec3ca3d49d181123 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C277-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C279-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C277-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C277-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C279-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-155 |
| filingDate | 2015-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-101498-A1 |
| titleOfInvention | PROCEDURE FOR THE PREPARATION OF COMPOUND N- (3,5-DIMETHYLPHENYL) -N- (2-TRIFLUOROMETILFENIL) GUANIDINE AND ITS CRYSTALLINE FORM A |
| abstract | Crystalline solid form A; to a pharmaceutical composition comprising them; and for use as a medicament, in particular for the treatment of a condition mediated by Rho-GTPase cellular proteins. Claim 1: Process for the preparation of the compound N- (3,5-dimethylphenyl) -N- (2-trifluoromethylphenyl) guanidine of formula (1), comprising reacting a salt of a compound of formula (2) or a mixture of the salt of the compound of formula (2) and a compound of formula (2) with a cyanamide compound of formula (3), in the presence of a polar organic solvent. Claim 10: The crystalline solid form A of formula (1) according to claim 9, having a DSC of 132.4 ° C. |
| priorityDate | 2015-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 23.