http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-101175-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a73cee5001ad08339ae751c10d9abf71 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-538 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 |
| filingDate | 2015-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4c53abe927ead1a203d1713797aa347e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b504e530ec79c9312a645844c33e8818 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_754803c4188d356417c808df90624c5c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_586764b31e3d0f4ff2afc3932520d6fd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5986eba9dde81f7b877df004e2ed6512 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c867e0ff6bc16b9cfe05c51af08d3ff http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_49f376d0acc2a328575bd3be0ee430a3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4647f871902032bb1beab8e4558aaf88 |
| publicationDate | 2016-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-101175-A1 |
| titleOfInvention | IMIDAZOPIRIDINES AND IMIDAZOPIRAZINAS AS INHIBITORS OF LSD1 |
| abstract | This refers to imidazo [1,5-a] pyridine and imidazo [1,5-a] pyrazine derivatives that are LSD1 inhibitors useful in the treatment of diseases such as cancer. Claim 1: A compound of formula (1), or a pharmaceutically acceptable salt thereof, characterized in that: X is N or CRX; ring A is C₆₋₁₀ aryl or 5-10 membered heteroaryl comprising carbon and 1, 2, 3, or 4 heteroatoms selected from N, O, and S, wherein said C₆₋₁₀ aryl and 5-10 membered heteroaryl they are optionally substituted with 1, 2, 3, or 4 substituents independently selected from RA; ring B is aryl C₆₋₁₀; 5-10 membered heteroaryl comprising carbon and 1, 2, 3 or 4 heteroatoms selected from N, O, and S; C₃₋₁₀ cycloalkyl; or 4-10 membered heterocycloalkyl comprising carbon and 1, 2, 3 or 4 heteroatoms selected from N, O, and S; wherein said C₆₋₁₀ aryl, 5-10 membered heteroaryl, C₃₋₁₀ cycloalkyl, and 4-10 membered heterocycloalkyl are optionally substituted with 1, 2, 3, or 4 substituents independently selected from RB; R¹ is halo, C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₁₋₆ haloalkyl, Cy¹, CN, ORᵃ¹, SRᵃ¹, C (O) Rᵇ¹, C (O) NRᶜ¹Rᵈ¹, C (O) ORᵃ¹, OC (O) Rᵇ¹, OC (O) NRᶜ¹Rᵈ¹, NRᶜ¹Rᵈ¹, NRᶜ¹C (O) Rᵇ¹, NRᶜ¹C (O) ORᵃ¹, NRᶜ¹C (O) NRᶜ¹Rᵈ¹, C (= NRᵉ¹) Rᵇ¹, C (= NRᵉ¹) NRᶜ¹Rᵈ¹, NRᶜ¹C (= NRᵉ¹ ) NRᶜ¹Rᵈ¹, NRᶜ¹S (O) Rᵇ¹, NRᶜ¹S (O) ₂Rᵇ¹, NRᶜ¹S (O) ₂NRᶜ¹Rᵈ¹, S (O) Rᵇ¹, S (O) NRᶜ¹Rᵈ¹, S (O) ₂Rᵇ¹, and S (O) ₂NRᶜ¹Rᵈ¹; wherein said C₁₋₆ alkyl, C₂₋₆ alkenyl, and C₂₋₆ alkynyl are optionally substituted with 1, 2, or 3 substituents independently selected from Cy¹, halo, CN, ORᵃ¹, SRᵃ¹, C (O) Rᵇ¹, C (O) NRᶜ¹Rᵈ¹, C (O) ORᵃ¹, OC (O) Rᵇ¹, OC (O) NRᶜ¹Rᵈ¹, NRᶜ¹Rᵈ¹, NRᶜ¹C (O) Rᵇ¹, NRᶜ¹C (O) ORᵃ¹, NRᶜ¹C (O) NRᶜ¹Rᵈ¹, C (= NRᵉ¹) Rᵇ¹, C (= NRᵉ¹) NRᶜ¹Rᵈ¹, NRᶜ¹C (= NRᵉ¹) NRᶜ¹Rᵈ¹, NRᶜ¹S (O) Rᵇ¹, NRᶜ¹S (O) ₂Rᵇ¹, NRᶜ¹S (O) ₂NRᶜ¹Rᵈ¹, S (O) Rᵇ¹, S (O) NRᶜ¹Rᵈ¹, S (O) ₂Rᵇ¹ and S (O) ₂NRᶜ¹Rᵈ¹; R³ is H, halo, C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₁₋₆ haloalkyl, Cy², CN, ORᵃ³, SRᵃ³, C (O) Rᵇ³, C (O) NRᶜ³Rᵈ³, C (O) ORᵃ³, OC (O) Rᵇ³, OC (O) NRᶜ³Rᵈ³, NRᶜ³Rᵈ³, NRᶜ³C (O) Rᵇ³, NRᶜ³C (O) ORᵃ³, NRᶜ³C (O) NRᶜ³Rᵈ³, C (= NRᵉ³) Rᵇ³, C (= NRᵉ³) NRᶜ³Rᵈ³, NRᶜ³C ( = NRᵉ³) NRᶜ³Rᵈ³, NRᶜ³S (O) Rᵇ³, NRᶜ³S (O) ₂Rᵇ³, NRᶜ³S (O) ₂NRᶜ³Rᵈ³, S (O) Rᵇ³, S (O) NRᶜ³Rᵈ³, S (O) ₂Rᵇ³, and S (O) ₂NRᶜ³Rᵈ³, C₁₋₆ alkyl, C₂₋₆ alkenyl, and C₂₋₆ alkynyl are optionally substituted with 1, 2, or 3 substituents selected from Cy², halo, CN, ORᵃ³, SRᵃ³, C (O) Rᵇ³, C (O) NRᶜ³Rᵈ³, C (O) ORᵃ³, OC (O) Rᵇ³, OC (O) NRᶜ³Rᵈ³, NRᶜ³Rᵈ³, NRᶜ³C (O) Rᵇ³, NRᶜ³C (O) ORᵃ³, NRᶜ³C (O) NRᶜ³Rᵈ³, C (= NRᵉ³) Rᵇ³, C (= NRᵉ³) NRᶜ³Rᵈ³, NRᶜ³C (= NRᵉ³) NRᶜ³Rᵈ³, NRᶜ³S (O) Rᵇ³, NRᶜ³S (O) ₂Rᵇ³, NRᶜ³S (O) ₂NRᶜ³Rᵈ³ , S (O) Rᵇ³, S (O) NRᶜ³Rᵈ³, S (O) ₂Rᵇ³ and S (O) ₂NRᶜ³Rᵈ³; R⁴ is Cy³, H, halo, C alquilo alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₁₋₆ haloalkyl, CN, ORᵃ², SRᵃ², C (O) Rᵇ², C (O) NRᶜ²Rᵈ², C (O) ORᵃ², OC (O) Rᵇ², OC (O) NRᶜ²Rᵈ², NRᶜ²Rᵈ², NRᶜ²C (O) Rᵇ², NRᶜ²C (O) ORᵃ², NRᶜ²C (O) NRᶜ²Rᵈ², C (= NRᵉ²) Rᵇ², C (= NRᵉ²) NRᶜ²Rᵈ², NRᶜ²C ( = NRᵉ²) NRᶜ²Rᵈ², NRᶜ²S (O) Rᵇ², NRᶜ²S (O) ₂Rᵇ², NRᶜ²S (O) ₂NRᶜ²Rᵈ², S (O) Rᵇ², S (O) NRᶜ²Rᵈ², S (O) ₂Rᵇ², and S (O) ₂NRᶜ²Rᵈ²; wherein said C₁₋₆ alkyl, C₂₋₆ alkenyl, and C₂₋₆ alkynyl are optionally substituted with 1, 2, or 3 substituents independently selected from Cy³, halo, CN, ORᵃ², SRᵃ², C (O) Rᵇ², C (O) NRᶜ²Rᵈ², C (O) ORᵃ², OC (O) Rᵇ², OC (O) NRᶜ²Rᵈ², NRᶜ²Rᵈ², NRᶜ²C (O) Rᵇ², NRᶜ²C (O) ORᵃ², NRᶜ²C (O) NRᶜ²Rᵈ², C (= NRᵉ²) Rᵇ², C (= NRᵉ²) NRᶜ²Rᵈ², NRᶜ²C (= NRᵉ²) NRᶜ²Rᵈ², NRᶜ²S (O) Rᵇ², NRᶜ²S (O) ₂Rᵇ², NRᶜ²S (O) ₂NRᶜ²Rᵈ², S (O) Rᵇ², S (O) NRᶜ²RᵈR, S (O) ᵇ² S (O) ₂NRᶜ²Rᵈ²; each RA is independently selected from halo, C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₁₋₆ haloalkyl, CN, NO₂, ORᵃ⁴, SRᵃ⁴, C (O) Rᵇ⁴, C (O) NRᶜ⁴Rᵈ⁴, C (O) ORᵃ⁴, OC (O) Rᵇ⁴, OC (O) NRᶜ⁴Rᵈ⁴, NRᶜ⁴Rᵈ⁴, NRᶜ⁴C (O) Rᵇ⁴, NRᶜ⁴C (O) ORᵃ⁴, NRᶜ⁴C (O) NRᶜ⁴Rᵈ⁴, C (= NRᵉ⁴) Rᵇ⁴, C (= NRᵉ⁴) NRᶜ⁴Rᵈ⁴, NRᶜ⁴C (= NRᵉ⁴) NRᶜ⁴Rᵈ⁴, NRᶜ⁴S (O) Rᵇ⁴, NRᶜ⁴S (O) ₂Rᵇ⁴, NRᶜ⁴S (O) ₂NRᶜ⁴Rᵈ⁴, S (O) Rᵇ⁴, S (O) NRᶜ⁴Rᵈ⁴, S (O) ₂Rᵇ⁴, and S (O) ₂NRᶜ⁴Rᵈ⁴, wherein said C₁₋₆ alkyl, C₂₋₆ alkenyl, and C₂₋₆ alkynyl are optionally substituted with 1, 2, or 3, substituents independently selected from halo, haloalkyl C₁₋₆, CN, NO₂, ORᵃ⁴, SRᵃ⁴ , C (O) Rᵇ⁴, C (O) NRᶜ⁴Rᵈ⁴, C (O) ORᵃ⁴, OC (O) Rᵇ⁴, OC (O) NRᶜ⁴Rᵈ⁴, NRᶜ⁴Rᵈ⁴, NRᶜ⁴C (O) Rᵇ⁴, NRᶜ⁴C (O) ORᵃ⁴, NRᶜ⁴C (O) NRᶜ⁴Rᵈ⁴ , C( = NRᵉ⁴) Rᵇ⁴, C (= NRᵉ⁴) NRᶜ⁴Rᵈ⁴, NRᶜ⁴C (= NRᵉ⁴) NRᶜ⁴Rᵈ⁴, NRᶜ⁴S (O) Rᵇ⁴, NRᶜ⁴S (O) ₂Rᵇ⁴, NRᶜ⁴S (O) ₂NRᶜ⁴Rᵈ⁴, S (O) Rᵇ⁴, S (O) NRᶜ⁴Rᵈ⁴, S (O) ₂Rᵇ⁴ and S (O) ₂NRᶜ⁴Rᵈ⁴; each RB is independently selected from Cy⁴, halo, C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₁₋₆ haloalkyl, = O, CN, NO₂, ORᵃ⁵, SRᵃ⁵, C (O) Rᵇ⁵, C (O) NRᶜ⁵Rᵈ⁵, C (O) ORᵃ⁵, OC (O) Rᵇ⁵, OC (O) NRᶜ⁵Rᵈ⁵, NRᶜ⁵Rᵈ⁵, NRᶜ⁵C (O) Rᵇ⁵, NRᶜ⁵C (O) ORᵃ⁵, NRᶜ⁵C (O) NRᶜ⁵Rᵈ⁵, C (= NRᵉ⁵) Rᵇ⁵, C (= NRᵉ⁵) NRᶜ⁵Rᵈ⁵, NRᶜ⁵C (= NRᵉ⁵) NRᶜ⁵Rᵈ⁵, NRᶜ⁵S (O) Rᵇ⁵, NRᶜ⁵S (O) ₂Rᵇ⁵, NRᶜ⁵S (O) ₂NRᶜ⁵Rᵈ⁵, S (O) Rᵇ⁵, S (O) NRᶜ⁵Rᵈ⁵, S (O) ₂Rᵇ⁵ and S (O) ₂NRᶜ⁵Rᵈ⁵, wherein said C₁₋₆ alkyl, C₂₋₆ alkenyl, and C₂₋₆ alkynyl are optionally substituted with 1, 2, or 3 substituents independently selected from Cy⁴, halo, haloalkyl C₁₋₆, CN, NO₂, ORᵃ⁵, SRᵃ⁵, C (O) Rᵇ⁵, C (O) NRᶜ⁵Rᵈ⁵, C (O) ORᵃ⁵, OC (O) Rᵇ⁵, OC (O) NRᶜ⁵Rᵈ⁵, NRᶜ⁵Rᵈ⁵, NRᶜ⁵C (O) Rᵇ⁵, NRᶜ⁵C (O) ORᵃ⁵, NRᶜ⁵C (O) NR ⁵Rᵈ⁵, C (= NRᵉ⁵) Rᵇ⁵, C (= NRᵉ⁵) NRᶜ⁵Rᵈ⁵, NRᶜ⁵C (= NRᵉ⁵) NRᶜ⁵Rᵈ⁵, NRᶜ⁵S (O) Rᵇ⁵, NRᶜ⁵S (O) ₂Rᵇ⁵, NRᶜ⁵S (O) ₂NRᶜ⁵Rᵈ⁵, S (O) Rᵇ⁵, S (O ) NRᶜ⁵Rᵈ⁵, S (O) ₂Rᵇ⁵, and S (O) ₂NRᶜ⁵Rᵈ⁵; RX is H, halo, C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₁₋₆ haloalkyl, CN, ORᵃ⁸, SRᵃ⁸, C (O) Rᵇ⁸, C (O) NRᶜ⁸Rᵈ⁸, C (O) ORᵃ⁸, OC (O) Rᵇ⁸, OC (O) NRᶜ⁸Rᵈ⁸, NRᶜ⁸Rᵈ⁸, NRᶜ⁸C (O) Rᵇ⁸, NRᶜ⁸C (O) ORᵃ⁸, NRᶜ⁸C (O) NRᶜ⁸Rᵈ⁸, C (= NRᵉ⁸) Rᵇ⁸, C (= NRᵉ⁸) NRᶜ⁸Rᵈ⁸, NRᶜ⁸C (= NRᵉ⁸ ) NRᶜ⁸Rᵈ⁸, NRᶜ⁸S (O) Rᵇ⁸, NRᶜ⁸S (O) ₂Rᵇ⁸, NRᶜ⁸S (O) ₂NRᶜ⁸Rᵈ⁸, S (O) Rᵇ⁸, S (O) NRᶜ⁸Rᵈ⁸, S (O) ₂Rᵇ⁸ or S (O) ₂NRᶜ⁸Rᵈ⁸; each Cy¹, Cy³, Cy⁴, and Cy⁵ are independently selected from C₆₋₁₀ aryl, C₃₋₁₀ cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl, each of which is optionally substituted with 1 , 2, 3, or 4 substituents independently selected from RCʸ; each Cy² is independently selected from phenyl, C₃₋₇ cycloalkyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl, each of which is optionally substituted with 1, 2, or 3 independently selected substituents of RCʸ; each RCʸ is selected from halo, C₁₋₄ alkyl, C₁₋₄ haloalkyl, C₁₋₄ cyanoalkyl, C₂₋₆ alkenyl C₂₋₆ alkynyl, phenyl, C₃₋₇ cycloalkyl, 5-6 membered heteroaryl, 4-7 heterocycloalkyl members, phenyl-C₁₋₄-alkyl, C₃₋₇-cycloalkyl-C₁₋₄- alkyl, (5-6 membered heteroaryl) -C₁₋₄- alkyl, (4-7 membered heterocycloalkyl) -C₁₋₄ alkyl, oxo, CN, NO₂, ORᵃ⁶, SRᵃ⁶, C (O) Rᵇ⁶, C (O) NRᶜ⁶Rᵈ⁶, C (O) ORᵃ⁶, OC (O) Rᵇ⁶, OC (O) NRᶜ⁶Rᵈ⁶, C (= NRᵉ⁶) NRᶜ⁶Rᵈ⁶, NRᶜ⁶C (= NRᵉ⁶) NRᶜ⁶Rᵈ⁶, NRᶜ⁶Rᵈ⁶, NRᶜ⁶C (O) Rᵇ⁶, NRᶜ⁶C (O) ORᵃ⁶, NRᶜ⁶C (O) NRᶜ⁶Rᵈ⁶, NRᶜ⁶S (O) Rᵇ⁶, NRᶜ⁶S (O) ₂Rᵇ⁶, NRᶜ⁶S (O) ₂NRᶜ⁶Rᵈ⁶, S (O) Rᵇ⁶, S ( O) NRᶜ⁶Rᵈ⁶, S (O) ₂Rᵇ⁶ and S (O) ₂NRᶜ⁶Rᵈ⁶, wherein said C₁₋₄ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, phenyl, C₃₋₇ cycloalkyl, 5-6 membered heteroaryl, heteroc 4-7 member icloalkyl, phenyl-C₁₋₄- alkyl, C₃₋₇-cycloalkyl-C₁₋₄- alkyl, (5-6 membered heteroaryl) -C₁₋₄- alkyl, and (4-7 membered heterocycloalkyl) -C₁₋₄ alkyl- are optionally substituted with 1, 2, or 3 substituents independently selected from C₁₋₄ alkyl, C₁₋₄ haloalkyl, C₁₋₄ cyanoalkyl, halo, CN, NO₂, ORᵃ⁶, SRᵃ⁶, C (O ) Rᵇ⁶, C (O) NRᶜ⁶Rᵈ⁶, C (O) ORᵃ⁶, OC (O) Rᵇ⁶, OC (O) NRᶜ⁶Rᵈ⁶, C (= NRᵉ⁶) NRᶜ⁶Rᵈ⁶, NRᶜ⁶C (= NRᵉ⁶) NRᶜ⁶Rᵈ⁶, NRᶜ⁶Rᵈ⁶, NRᶜ⁶C (O) Rᵇ⁶, NRᶜ⁶C (O) ORᵃ⁶, NRᶜ⁶C (O) NRᶜ⁶Rᵈ⁶, NRᶜ⁶S (O) Rᵇ⁶, NRᶜ⁶S (O) ₂Rᵇ⁶, NRᶜ⁶S (O) ₂NRᶜ⁶Rᵈ⁶, S (O) Rᵇ⁶, S (O) NRᶜ⁶Rᵈ⁶, S (O) ₂Rᵇ⁶ and S (O ) ₂NRᶜ⁶Rᵈ⁶; each Rᵃ¹ is independently selected from H, C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, and Cy⁵, wherein said C₁₋₆ alkyl, C₂₋₆ alkenyl, and C₂₋₆ alkynyl are optionally substituted with 1 , 2, or 3 substituents independently selected from Cy⁵, halo, CN, ORᵃ⁷, SRᵃ⁷, C (O) Rᵇ⁷, C (O) NRᶜ⁷Rᵈ⁷, C (O) ORᵃ⁷, OC (O) Rᵇ⁷, OC (O) NRᶜ⁷Rᵈ⁷ , NRᶜ⁷Rᵈ⁷, NRᶜ⁷C (O) Rᵇ⁷, NRᶜ⁷C (O) ORᵃ⁷, NRᶜ⁷C (O) NRᶜ⁷Rᵈ⁷, C (= NRᵉ⁷) Rᵇ⁷, C (= NRᵉ⁷) NRᶜ⁷Rᵈ⁷, NRᶜ⁷C (= NRᵉ⁷) NRᶜ⁷Rᵈ⁷, NRᶜ⁷S (O) Rᵇ⁷, NRᶜ⁷S ( O) ₂Rᵇ⁷, NRᶜ⁷S (O) ₂NRᶜ⁷Rᵈ⁷, S (O) Rᵇ⁷, S (O) NRᶜ⁷Rᵈ⁷, S (O) ₂Rᵇ⁷ and S (O) ₂NRᶜ⁷Rᵈ⁷; each Rᵇ¹, Rᶜ¹, and Rᵈ¹ is independently selected from H, C₁₋₆ alkyl, C₁₋₄ haloalkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₆₋₁₀ aryl, C₃₋₁₀ cycloalkyl, 5-10 heteroaryl members, 4-10 membered heterocycloalkyl, C₆₋₁₀-C₁₋₄-alkyl aryl, C₃₋₁₀-C₁₋₄- cycloalkyl, (5-10 membered heteroaryl) -C₁₋₄- alkyl, and (4-heterocycloalkyl) - 10 members) -C₁₋₄ alkyl-, wherein said C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₆₋₁₀ aryl, C₃₋₁₀ cycloalkyl, 5-10 membered heteroaryl, 4-10 heterocycloalkyl members, aryl C₆₋₁₀-C₁₋₄-alkyl, cycloalkyl C ciclo-alkyl C₁₋₄, (5-10 membered heteroaryl) -C₁₋₄ alkyl-, and (4-10 membered heterocycloalkyl) -C₁ alkyl ₋₄- are optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from C₁₋₄ alkyl, haloalkyl C₁₋₄, cyanoalkyl C₁₋₄, halo, CN, ORᵃ⁸, SRᵃ⁸, C (O) Rᵇ⁸, C (O) NRᶜ⁸Rᵈ⁸, C (O) ORᵃ⁸, OC (O) Rᵇ⁸, OC (O) NRᶜ⁸Rᵈ⁸, NRᶜ⁸Rᵈ⁸, NRᶜ⁸C (O) Rᵇ⁸, NRᶜ⁸C (O) NRᶜ⁸Rᵈ⁸, NRᶜ⁸C (O) ORᵃ⁸, C (= NRᵉ⁸) NRᶜ⁸Rᵈ⁸, NRᶜ⁸C (= NRᵉ⁸) NRᶜ⁸Rᵈ⁸, S (O) Rᵇ⁸, S (O) NRᶜ⁸Rᵈ⁸, S (O) ₂Rᵇ⁸, NRᶜ⁸S (O) ₂Rᵇ⁸, NRᶜ⁸S (O) ₂NRᶜ⁸Rᵈ⁸ and S (O) ₂NRᶜ⁸Rᵈ⁸; or Rᶜ¹ and Rᵈ¹ together with an N atom to which they are attached form a heterocycloalkyl group of 4, 5, 6, or 7 members optionally substituted with 1, 2, or 3 substituents independently selected from C₁₋₆ alkyl, cycloalkyl C₃₋₇, 4-7 membered heterocycloalkyl, C₆₋₁₀ aryl, 5-6 membered heteroaryl, C₁₋₆ haloalkyl, halo, CN, ORᵃ⁸, SRᵃ⁸, C (O) Rᵇ⁸, C (O) NRᶜ⁸Rᵈ⁸, C ( O) ORᵃ⁸, OC (O) Rᵇ⁸, OC (O) NRᶜ⁸Rᵈ⁸, NRᶜ⁸Rᵈ⁸, NRᶜ⁸C (O) Rᵇ⁸, NRᶜ⁸C (O) NRᶜ⁸Rᵈ⁸, NRᶜ⁸C (O) ORᵃ⁸, C (= NRᵉ⁸) NRᶜ⁸Rᵈ⁸, NRᶜ⁸C (= NRᵉ⁸) NRᶜ⁸Rᵈ⁸, S (O) Rᵇ⁸, S (O) NRᶜ⁸Rᵈ⁸, S (O) ₂Rᵇ⁸, NRᶜ⁸S (O) ₂Rᵇ⁸, NRᶜ⁸S (O) ₂NRᶜ⁸Rᵈ⁸, and S (O) ₂NRᶜ⁸Rᵈ⁸, wherein said C₁₋₆ alkyl, C₃₋₇ cycloalkyl, heterocycloalkyl 4-7 members, C₆₋₁₀ aryl, and 5-6 membered heteroaryl are optionally substituted with 1, 2, or 3 substituents selection independently attached to halo, C₁₋₄ alkyl, C₁₋₄ haloalkyl, C₁₋₄ cyanoalkyl, CN, ORᵃ⁸, SRᵃ⁸, C (O) Rᵇ⁸, C (O) NRᶜ⁸Rᵈ⁸, C (O) ORᵃ⁸, OC (O) Rᵇ⁸, OC (O) NRᶜ⁸Rᵈ⁸, NRᶜ⁸Rᵈ⁸, NRᶜ⁸C (O) Rᵇ⁸, NRᶜ⁸C (O) NRᶜ⁸Rᵈ⁸, NRᶜ⁸C (O) ORᵃ⁸, C (= NRᵉ⁸) NRᶜ⁸Rᵈ⁸, NRᶜ⁸C (= NRᵉ⁸) NRᶜ⁸Rᵈ⁸, S (O) Rᵇ⁸, S ( O) NRᶜ⁸Rᵈ⁸, S (O) ₂Rᵇ⁸, NRᶜ⁸S (O) ₂Rᵇ⁸, NRᶜ⁸S (O) ₂NRᶜ⁸Rᵈ⁸ and S (O) ₂NRᶜ⁸Rᵈ⁸; each Rᵃ², Rᵇ², Rᶜ², and Rᵈ² are independently selected from H, C₁₋₆ alkyl, C₁₋₄ haloalkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, Calo aryl, C₃₋₁₀ cycloalkyl, 5-10 heteroaryl members, 4-10 membered heterocycloalkyl, C₆₋₁₀-C₁₋₄-alkyl aryl, C₃₋₁₀-C₁₋₄- cycloalkyl, (5-10 membered heteroaryl) -C₁₋₄- alkyl, and (heterocycloalkyl of 4-10 members) -C₁₋₄ alkyl-, wherein said C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₆₋₁₀ aryl, C₃₋₁₀ cycloalkyl, 5-10 membered heteroaryl, 4 - heterocycloalkyl 10 members, Cil-C₁₋₄-Cil-alkyl, C₁₋₄-Cal- cycloalkyl, (5-10 membered heteroaryl) -C₁₋₄- alkyl, and (4-10 membered heterocycloalkyl) - C₁₋₄-alkyl are optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from C₁₋₄ alkyl, h Calalkyl, C₁₋₄ cyanoalkyl, halo, CN, ORᵃ⁸, SRᵃ⁸, C (O) Rᵇ⁸, C (O) NRᶜ⁸Rᵈ⁸, C (O) ORᵃ⁸, OC (O) Rᵇ⁸, OC (O) NRᶜ⁸Rᵈ⁸, NRᶜ⁸Rᵈ⁸, NRᶜ⁸C (O) Rᵇ⁸, NRᶜ⁸C (O) NRᶜ⁸Rᵈ⁸, NRᶜ⁸C (O) ORᵃ⁸, C (= NRᵉ⁸) NRᶜ⁸Rᵈ⁸, NRᶜ⁸C (= NRᵉ⁸) NRᶜ⁸Rᵈ⁸, S (O) Rᵇ⁸, S (O) NRᶜ⁸Rᵈ⁸, S (O) ₂Rᵇ⁸, NRᶜ⁸S (O) ₂Rᵇ⁸, NRᶜ⁸S (O) ₂NRᶜ⁸Rᵈ⁸ and S (O) ₂NRᶜ⁸Rᵈ⁸, or Rᶜ² and Rᵈ² together with an N atom to which they are attached form a heterocycloalkyl group of a 4, 5, 6, or 7 members optionally substituted with 1, 2, or 3 substituents independently selected from C₁₋₆ alkyl, C₃₋₇ cycloalkyl, 4-7 membered heterocycloalkyl, C₆₋₁₀ aryl, 5-6 membered heteroaryl, C₁₋₆ haloalkyl, halo, CN, ORᵃ⁸, SRᵃ⁸, C (O) Rᵇ⁸, C (O) NRᶜ⁸Rᵈ⁸, C (O) ORᵃ⁸, OC (O) Rᵇ⁸, OC (O) NRᶜ⁸Rᵈ⁸, NRᶜ⁸Rᵈ⁸, NRᶜ⁸C (O) Rᵇ⁸, NRᶜ⁸C (O) NRᶜ⁸ Rᵈ⁸, NRᶜ⁸C (O) ORᵃ⁸, C (= NRᵉ⁸) NRᶜ⁸Rᵈ⁸, NRᶜ⁸C (= NRᵉ⁸) NRᶜ⁸Rᵈ⁸, S (O) Rᵇ⁸, S (O) NRᶜ⁸Rᵈ⁸, S (O) ₂Rᵇ⁸, NRᶜ⁸S (O) ₂Rᵇ⁸, NRᶜ⁸S (O) ₂NRᶜ⁸Rᵈ⁸ and S (O) ₂NRᶜ⁸Rᵈ⁸, wherein said C₁₋₆ alkyl, C₃₋₇ cycloalkyl, 4-7 membered heterocycloalkyl, C₆₋₁₀ aryl, and 5-6 membered heteroaryl are optionally substituted with 1, 2, or 3 substituents independently selected from halo, C₁₋₄ alkyl, C₁₋₄ haloalkyl, C₁₋₄ cyanoalkyl, CN, ORᵃ⁸, SRᵃ⁸, C (O) Rᵇ⁸, C (O) NRᶜ⁸Rᵈ⁸, C (O) ORᵃ⁸, OC (O) Rᵇ⁸, OC (O) NRᶜ⁸Rᵈ⁸, NRᶜ⁸Rᵈ⁸, NRᶜ⁸C (O) Rᵇ⁸, NRᶜ⁸C (O) NRᶜ⁸Rᵈ⁸, NRᶜ⁸C (O) ORᵃ⁸, C (= NRᵉ⁸) NRᶜ⁸Rᵈ⁸, NRᶜ⁸C (= NRᵉ⁸) NRᶜ⁸Rᵈ⁸, S (O) Rᵇ⁸, S ( O) NRᶜ⁸Rᵈ⁸, S (O) ₂Rᵇ⁸, NRᶜ⁸S (O) ₂Rᵇ⁸, NRᶜ⁸S (O) ₂NRᶜ⁸Rᵈ⁸, and S (O) ₂NRᶜ⁸Rᵈ⁸; each Rᵃ³, Rᵇ³, Rᶜ³, and Rᵈ³ is independently selected from H, C₁₋₆ alkyl, C₁₋₄ haloalkyl, C₂₋₆ alkenyl, and C₂₋₆ alkynyl, wherein said C₁₋₆ alkyl, C₂₋₆ alkenyl, and C₂₋₆ alkynyl are optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from C₁₋₄ alkyl, C₁₋₄ haloalkyl, C₁₋₄ cyanoalkyl, halo, CN, ORᵃ⁸, SRᵃ⁸, C ( O) Rᵇ⁸, C (O) NRᶜ⁸Rᵈ⁸, C (O) ORᵃ⁸, OC (O) Rᵇ⁸, OC (O) NRᶜ⁸Rᵈ⁸, NRᶜ⁸Rᵈ⁸, NRᶜ⁸C (O) Rᵇ⁸, NRᶜ⁸C (O) NRᶜ⁸Rᵈ⁸, NRᶜ⁸C (O) ORᵃ⁸, C ( = NRᵉ⁸) NRᶜ⁸Rᵈ⁸, NRᶜ⁸C (= NRᵉ⁸) NRᶜ⁸Rᵈ⁸, S (O) Rᵇ⁸, S (O) NRᶜ⁸Rᵈ⁸, S (O) ₂Rᵇ⁸, NRᶜ⁸S (O) ₂Rᵇ⁸, NRᶜ⁸S (O) ₂NRᶜ⁸Rᵈ⁸, and S (O) ₂NRᶜ⁸Rᵈ⁸; or Rᶜ³ and Rᵈ³ together with an N atom to which they are attached form a heterocycloalkyl group of 4, 5, 6, or 7 members optionally substituted with 1, 2, or 3 substituents independently selected from C₁₋₆ alkyl, haloalkyl C₁₋₆, halo, CN, ORᵃ⁸, SRᵃ⁸, C (O) Rᵇ⁸, C (O) NRᶜ⁸Rᵈ⁸, C (O) ORᵃ⁸, OC (O) Rᵇ⁸, OC (O) NRᶜ⁸Rᵈ⁸, NRᶜ⁸Rᵈ⁸, NRᶜ⁸C (O) Rᵇ⁸, NRᶜ⁸C (O) NRᶜ⁸Rᵈ⁸, NRᶜ⁸C (O) ORᵃ⁸, C (= NRᵉ⁸) NRᶜ⁸Rᵈ⁸, NRᶜ⁸C (= NRᵉ⁸) NRᶜ⁸Rᵈ⁸, S (O) Rᵇ⁸, S (O) NRᶜ⁸Rᵈ⁸, S (O) ₂Rᵇ⁸, NRᶜ⁸S (O) ₂Rᵇ⁸, NRᶜ⁸S (O) ₂NRᶜ⁸Rᵈ⁸, and S (O) ₂NRᶜ⁸Rᵈ⁸; each Rᵃ⁴, Rᵇ⁴, Rᶜ⁴, and Rᵈ⁴ is independently selected from H, C₁₋₆ alkyl, C₁₋₄ haloalkyl, C₂₋₆ alkenyl, and C₂₋₆ alkynyl, wherein said C₁₋₆ alkyl, C₂₋₆ alkenyl, and C₂₋₆ alkynyl are optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from C₁₋₄ alkyl, C₁₋₄ haloalkyl, C₁₋₄ cyanoalkyl, halo, CN, ORᵃ⁸, SRᵃ⁸, C ( O) Rᵇ⁸, C (O) NRᶜ⁸Rᵈ⁸, C (O) ORᵃ⁸, OC (O) Rᵇ⁸, OC (O) NRᶜ⁸Rᵈ⁸, NRᶜ⁸Rᵈ⁸, NRᶜ⁸C (O) Rᵇ⁸, |
| priorityDate | 2014-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 35.