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filingDate 2015-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2016-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber AR-100892-A1
titleOfInvention COMPOSITIONS AND METHODS FOR THE TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA AND SMALL LYMPHOCYT LEUKEMIA THROUGH THE USE OF A BRUTON TIROSIN QUINASA INHIBITOR
abstract Pharmaceutical compositions for the treatment of hematologic malignancies comprising a combination of a BTK inhibitor and an anti-CD20 antibody. Claim 2: The composition of claim 1, wherein the BTK inhibitor is of formula (1), or a pharmaceutically acceptable salt, co-crystal, solvate or hydrate thereof. Claim 7: The composition of any one of claims 1 to 6, further comprising an anticoagulant or antiplatelet agent, wherein the anticoagulant or antiplatelet agent is selected from the group consisting of clopidogrel, prasugrel, ticagrelor, ticlopidine, warfarin, acenocoumarol, dicumarol , fenprocumen, heparaine, low molecular weight heparin, fondaparinux, and idraparinux.
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