http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-100252-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_006e91eddabe95ad7aa889123d31cb9a |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2015-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd62982a7a521fea582b166a32d3bf9e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b7baa41173c505d5a2931d03be250846 |
| publicationDate | 2016-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-100252-A2 |
| titleOfInvention | IMPROVED CYTOTOXIC AGENTS UNDERSTANDING MAITANSINOIDS |
| abstract | Claim 1: A maitansinoid of the formula (1): May-Q-CR¹R²SZ (1) wherein May represents a maitansinoid, Q-CR¹R²SZ represents an acylated amino acid group at positions C-3, hydroxymethyl C-14, hydroxy C- 15, or C-20 demethyl of said maitansinoid, Z represents H, SR or -COR, where R is a linear alkyl or alkenyl radical of 1 to 10 carbon atoms, or branched or cyclic alkyl or alkenyl of 3 to 10 atoms of carbon or an aryl or heterocyclic aromatic or heterocycloalkyl radical, substituted or unsubstituted, characterized in that R¹ and R² independently represent each other linear alkyl or alkenyl with 1 to 10 carbon atoms, branched or cyclic alkyl or alkenyl having 3 to 10 carbon atoms , phenyl, substituted phenyl or an aromatic heterocyclic radical or heterocycloalkyl, and also, one of R¹ and R² may be H, and wherein the acyl group has a linear chain length of at least three carbon atoms. Claim 2: A compound represented by the formula (2), wherein: Y represents (CR⁷R⁸) ₗ (CR⁹ = CR¹⁰) ₚ (C ° C) qAr (CR⁵R⁶) ₘDᵘ (CR¹¹ = CR¹²) ʳ (C ° C) ₛBₜ (CR³R⁴) ₙCR¹R²SZ , in which A, B, D are cycloalkyl or cycloalkenyl radicals with 3-10 carbon atoms, simple aryl or substituted aryl or an aromatic heterocyclic radical or heterocycloalkyl; R³, R⁴, R⁵, R⁶, R⁷, R⁸, R⁹, R¹¹ and R¹² are each independently H, linear alkyl or alkenyl with 1 to 10 carbon atoms, branched or cyclic branched alkyl or alkenyl with 3 to 10 carbon atoms , phenyl, substituted phenyl or an aromatic heterocyclic radical or heterocycloalkyl; l, m, n, o, p, q, r, s, and t are each independently from each other 0 or an integer from 1 to 5, provided that at least two of l, m, n, o, p, q , r, syt are not zero at any given time; Z is H, SR or -COR, where R is linear alkyl or alkenyl having 1 to 10 carbon atoms, branched or cyclic alkyl or alkenyl having 3 to 10 carbon atoms, or simple or substituted aryl or an aromatic heterocyclic radical or heterocycloalkyl, characterized in that R¹ and R² independently represent each other linear alkyl or alkenyl with 1 to 10 carbon atoms, branched or cyclic alkyl or alkenyl with 3 to 10 carbon atoms, phenyl, substituted phenyl or an aromatic or heterocycloalkyl heterocyclic radical, and likewise R² can be H. |
| priorityDate | 2015-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 21.