http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-100020-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69ece09bafee7e0c49d1f7951a3faa2c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2014-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e09a5dfff25011b648850bdcb3fee2db |
| publicationDate | 2016-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-100020-A1 |
| titleOfInvention | PROCESS TO PREPARE (R) -5-BROMO-4- (3-AMINO) PIPERIDIN-1-IL) -3- (CYCLOPROPANCARBOXAMIDE) -1H-PIRROLO [2,3-B] PYRIDINE |
| abstract | This provides processes for the preparation of those useful in the preparation of compounds that can be used as CHK1 inhibitors. Claim 1: A process for preparing (R) -5-bromo-4- (3-amino) piperidin-1-yl) -3 (cyclopropancarboxamido) -1H-pyrrolo [2,3-b] pyridine of formula (1) which comprises the step of reacting a compound of formula (2) where X is halogen, with a compound of formula (3) where R is an amino protecting group, to provide a compound of formula (4). Claim 12: The process of any one of claims 1 to 11, further comprising the step of subjecting a compound of formula (4) wherein R is an amino protecting group, to a reduction of nitro to obtain a compound of formula (5 ). Claim 18: The process of any of claims 12 to 17 further comprising the step of reacting a compound of formula (5) with a compound of formula (6) wherein R donde is selected from the group consisting of chlorine, fluorine, bromide and OR², where R² is selected from the group consisting of cyclopropylcarbonyl, isobutylcarbonyl, isopropylcarbonyl, ethylcarbonyl, methylcarbonyl, 2-pyridyl, N-succinimide, to obtain a compound of formula (7). Claim 19: The process of claim 18 further comprising the step of removing the protecting group R in the compound of formula (7) to obtain (R) -5-bromo-4- (3- (amino) piperidin-1il) -3- (cyclopropancarboxamido) -1H-pyrrolo [2,3-b] pyridine of formula (1). |
| priorityDate | 2013-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.