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filingDate 2015-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2016-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber AR-099900-A1
titleOfInvention FILLINGS FOR SOFT FABRICS WITH POLYSACARIDS WITH IMPROVED PERSISTENCE, KIT, PROCEDURE, USE
abstract Claim 1: An injectable soft tissue filler composition in the form of a gel, comprising heparosan and hyaluronic acid (HA), or a salt thereof, crosslinked with 1,4-butanediol diglycidic ether (BDDE) to form a matrix reticulated HA-heparosan. Claim 10: The injectable soft tissue filler composition of any one of claims 1 to 9, wherein the composition further comprises particles having an average particle size of about 1 mm to about 1,000 mm, wherein the particles are, for example, ceramic particles, particularly calcium hydroxyapatite particles, and where the ceramic particles are contained, for example, in the injectable soft tissue filler composition in an amount of about 5% by weight and about 60% by weight, and / or where The composition further comprises at least one active substance, for example, an anesthetic agent, particularly lidocaine, more particularly lidocaine in an amount between about 0.05% by weight and about 5.0% by weight, based on the total weight of the injectable soft tissue filler composition, and / or where the composition further comprises one or var ios compounds selected from the group consisting of polyols, vitamins, amino acids, metals and minerals.
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