| abstract |
An epothilone analogue, represented by formula (1), and any solvate or hydrates thereof, which is used in the treatment of a patient in need of intravenous infusion treatment with an effective amount of a pharmaceutical composition, wherein said composition Pharmaceutical is formed by mixing the contents of the bottles of a pharmaceutical preparation comprising, in separate bottles, a lyophilized epothilone analogue and an amount of solvent for that so that when the contents of said bottles are combined, the resulting solution contains from 2 mg / mL to 4 mg / mL of said analog, said solvent comprises a mixture of equal parts by volume of dehydrated ethanol and a suitable nonionic surfactant, said analog being represented by the formula (1), to perform the solution of said analog of lyophilized epothilone and dilute the resulting solution with an amount of a suitable parenteral diluent so that the concentration of said analogue therein will be from 0.1 mg / mL to 0.9 mg / mL. Use of an epothilone analogue of formula (1) for the preparation of a medicament and pharmaceutical composition suitable for parenteral administration. Claim 3: The epothilone analog according to claim 1 or the use according to claim 2, characterized in that said diluent is Lactated Ring Injection. Claim 4: A pharmaceutical composition suitable for parenteral administration, characterized in that it comprises a compound represented by the formula (1) and its solvates or hydrates; dehydrated alcohol; and a nonionic surfactant. Claim 5: The composition according to claim 4, characterized in that the surfactant is polyethoxylated risin oil. |