| abstract |
Claim 1: Compounds of formula (1) wherein R¹, R², R³ and R⁴ are independently selected from H, alkyl and cycloalkyl; R⁵, R⁷ and R⁹ are independently selected from H or alkyl; R⁸ and R¹¹ together form -CH₂-CH₂-; R¹⁰ is H or R¹⁰ and R¹¹ together form - (CH₂) ʷ-; or R⁶ and R⁹ together form -CH₂-, R⁸ is H and R¹⁰ and R¹¹ together form -CH₂-; A is -C (O) - or -S (O) ₂-; B is -C- or -N-; R² is cycloalkyl or substituted heteroaryl, in which substituted heteroaryl is substituted with one to three substituents independently selected from H, alkyl, cycloalkyl, hydroxy, alkoxy, cyano and halogen; R¹³ is halogen, cyano, alkoxy or haloalkoxy; R¹⁴ is H, alkyl or cycloalkyl; R¹⁵ is H, alkyl, cycloalkyl or halogen; m, n and p are independently selected between zero and 1; w is 1, 2 or 3; and pharmaceutically acceptable salts thereof. |